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Diabetes mellitus degenerates cisplatin-induced nephrotoxicity in short hydration method: a propensity score-matching analysis

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Title: Diabetes mellitus degenerates cisplatin-induced nephrotoxicity in short hydration method: a propensity score-matching analysis
Authors: Saito, Yoshitaka Browse this author →KAKEN DB
Sakamoto, Tatsuhiko Browse this author
Takekuma, Yoh Browse this author →KAKEN DB
Kobayashi, Masaki Browse this author →KAKEN DB
Okamoto, Keisuke Browse this author
Shinagawa, Naofumi Browse this author →KAKEN DB
Shimizu, Yasushi Browse this author →KAKEN DB
Kinoshita, Ichiro Browse this author →KAKEN DB
Sugawara, Mitsuru Browse this author →KAKEN DB
Issue Date: 17-Dec-2022
Publisher: Nature Portfolio
Journal Title: Scientific reports
Volume: 12
Start Page: 21819
Publisher DOI: 10.1038/s41598-022-26454-x
Abstract: Cisplatin (CDDP)-induced nephrotoxicity (CIN) is dose-limiting. We revealed that co-administration of non-steroid anti-inflammatory drugs and baseline comorbidity of diabetes mellitus (DM) are associated with CIN development in the short hydration method; however, the results were accessorily obtained without appropriate power calculation. This study aimed to demonstrate the influence of DM complications on CIN incidence in a real-world setting. Lung cancer patients receiving CDDP (>= 75 mg/m2)-containing regimens with a short hydration method (n = 227) were retrospectively evaluated. The patients were divided into control and baseline DM complication groups. The primary endpoint was the evaluation of CIN incidence between the groups. Propensity score-matching was performed to confirm the robustness of the primary analysis results. CIN occurred in 6.8% of control and 27.0% of DM patients, respectively, with a significant difference in all-patient populations (P = 0.001). In addition, variation of serum creatinine and creatinine clearance significantly worsened in DM patients. Similar results were obtained in a propensity-matched population. Multivariate logistic regression analysis found that DM complication is a singular risk factor for CIN development (adjusted odds ratio; 4.31, 95% confidence interval; 1.62-11.50, P = 0.003). In conclusion, our study revealed that baseline DM complications significantly worsen CIN.
Type: article
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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