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Analysis of the triplet-state kinetics of a photosensitizer for photoimmunotherapy by fluorescence correlation spectroscopy
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| Title: | Analysis of the triplet-state kinetics of a photosensitizer for photoimmunotherapy by fluorescence correlation spectroscopy |
| Authors: | Takakura, Hideo Browse this author | | Goto, Yuto Browse this author | | Kitamura, Akira Browse this author →KAKEN DB | | Yoshihara, Toshitada Browse this author | | Tobita, Seiji Browse this author | | Kinjo, Masataka Browse this author →KAKEN DB | | Ogawa, Mikako Browse this author →KAKEN DB |
| Keywords: | Photoimmunotherapy | | Silicon phthalocyanine | | Intersystem crossing quantum yield | | Fluorescence correlation spectroscopy | | Triplet state |
| Issue Date: | 1-Mar-2021 |
| Publisher: | Elsevier |
| Journal Title: | Journal of photochemistry and photobiology a-chemistry |
| Volume: | 408 |
| Start Page: | 113094 |
| Publisher DOI: | 10.1016/j.jphotochem.2020.113094 |
| Abstract: | Herein, we evaluated the intersystem crossing quantum yield (Phi(ISC)) of a silicon phthalocyanine derivatized from IRDye700DX (IR700) which is used as a photosensitizer for photoimmunotherapy (PIT), using fluorescence correlation spectroscopy (FCS). The calculated Phi(ISC) was 0.019 +/- 0.002. The FCS measurement was validated by experiment in the presence of potassium iodide, which can change the kinetics of the relaxation process in the excited state. |
| Rights: | © <2021>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/88660 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 高倉栄男
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