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Intramolecular Hydrogen Atom Transfer Hydroarylation of Alkenes toward δ-Lactams Using Cobalt-Photoredox Dual Catalysis
| Title: | Intramolecular Hydrogen Atom Transfer Hydroarylation of Alkenes toward δ-Lactams Using Cobalt-Photoredox Dual Catalysis |
| Authors: | Yamaguchi, Yuto Browse this author | | Seino, Yusuke Browse this author | | Suzuki, Akihiko Browse this author | | Kamei, Yuji Browse this author | | Yoshino, Tatsuhiko Browse this author →KAKEN DB | | Kojima, Masahiro Browse this author →KAKEN DB | | Matsunaga, Shigeki Browse this author →KAKEN DB |
| Issue Date: | 21-Mar-2022 |
| Publisher: | American Chemical Society |
| Journal Title: | Organic letters |
| Volume: | 24 |
| Issue: | 12 |
| Start Page: | 2441 |
| End Page: | 2445 |
| Publisher DOI: | 10.1021/acs.orglett.2c00700 |
| Abstract: | Intramolecular hydroarylation of alkenes through hydrogen atom transfer (HAT) represents a robust method to prepare benzo-fused heterocycles. However, the reported methods have limitations in a variety of accessible cyclic scaffolds. Here we report a dual cobalt- and photoredox-catalyzed HAT hydroarylation of alkenes that is characterized by higher efficiency in the synthesis of a δ-lactam compared to established protocols. The proposed mechanism is supported by experiments and DFT calculations. |
| Rights: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/articlesonrequest/AOR-HSSRMXZDGPCXCGYB4RZG. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/88781 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 小島 正寛
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