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An attempt to consider cooperativity in helical-sense preferences induced in fused macrocycles
| Title: | An attempt to consider cooperativity in helical-sense preferences induced in fused macrocycles |
| Authors: | Katoono, Ryo Browse this author →KAKEN DB | | Kudo, Takaaki Browse this author | | Kawai, Shunsuke Browse this author |
| Issue Date: | 21-Apr-2023 |
| Publisher: | Royal Society of Chemistry |
| Journal Title: | Organic & biomolecular chemistry |
| Start Page: | 2562 |
| End Page: | 2569 |
| Publisher DOI: | 10.1039/d3ob00171g |
| Abstract: | We synthesized bis and tris(macrocycle)s in which a two- or three-fold macrocycle was fused and each adopted twisted forms with M- or P-helicity. According to the sense of twisting in each element, diverse conformations can be generated in a molecule. We present two types of conformational preferences. One is the innate preference for a helical form with an identical sense of twisting throughout the entire molecule. The other is the helical-sense preference for a particular sense of twisting. We were interested in the relationship between K-n and (K-1)(n), where K-n is an equilibrium constant for the conformational interconversion between two helical forms (MM and PP, MMM and PPP) and n is the number of elements, since we considered that the relationship could be a metric to see the interinfluence among these macrocyclic elements in a single molecule. Through VT measurements in H-1 NMR and CD spectroscopy, we attempted to quantify the helical-sense preferences induced in the fused macrocycles (n = 2 and 3) to compare K-n and (K-1)(n). |
| Type: | article |
| URI: | http://hdl.handle.net/2115/88992 |
| Appears in Collections: | 理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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