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Behavior of Stimulus Response Signals in a Rat Cortical Neuronal Network Under Xe Pressure

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Title: Behavior of Stimulus Response Signals in a Rat Cortical Neuronal Network Under Xe Pressure
Authors: Uchida, T. Browse this author →KAKEN DB
Kubota, T. Browse this author
Tanabe, R. Browse this author
Yamazaki, K. Browse this author
Gohara, K. Browse this author
Keywords: multi-electrode array
xenon (Xe) pressure
pulse electrical stimulus
synaptic signal transduction
Hill equation
Issue Date: 1-Aug-2022
Publisher: Elsevier
Journal Title: Neuroscience
Volume: 496
Start Page: 38
End Page: 51
Publisher DOI: 10.1016/j.neuroscience.2022.05.027
Abstract: cultured on a multi-electrode array show not only spontaneous firing, but also networkspecific burst firing, the latter of which develops into synchronous bursting. Such synchronous bursting can be suppressed by exposure to xenon (Xe) gas. To better understand such suppression of bursting by Xe, we investigate here whether signal transmission between neurons is also suppressed under these conditions. In these experiments, we apply a pulse electrical-stimulus to one electrode and observe the response signals within 10 ms at other active electrodes. When put under a sufficient Xe pressure, some response signals become delayed or vanish after disappearance of synchronous-bursts, particularly signals passing through multiple synaptic bonds. Such bonds have a high probability of having delayed or vanishing signals when the Xe pressure is above 0.3 MPa. The pressure dependence of the response ratio to the stimulus suggests that Xe suppresses multiple points of action simultaneously when suppressing synaptic signal transduction, as observed in the suppression of the synchronized bursting. In addition, we find that the signal that transmits not via synaptic bonding (axon conduction) is also suppressed under Xe gas pressures over 0.3 MPa. Therefore, we conclude that Xeinduced suppression of synchronized bursting is caused mainly by a decrease in the apparent number of active neurons that contribute to the neuronal network, a decrease due to inhibition of signal transmission via synaptic connections.(c) 2022 IBRO. Published by Elsevier Ltd. All rights reserved.
Rights: © <2022>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 内田 努

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