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Clinical and radiological findings of glioblastomas harboring a BRAF V600E mutation

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Title: Clinical and radiological findings of glioblastomas harboring a BRAF V600E mutation
Authors: Ishi, Yukitomo Browse this author →KAKEN DB
Yamaguchi, Shigeru Browse this author
Okamoto, Michinari Browse this author
Sawaya, Ryosuke Browse this author
Endo, Shogo Browse this author
Motegi, Hiroaki Browse this author
Terasaka, Shunsuke Browse this author
Tanei, Zen-ichi Browse this author
Hatanaka, Kanako C. Browse this author
Tanaka, Shinya Browse this author →KAKEN DB
Fujimura, Miki Browse this author →KAKEN DB
Keywords: BRAF V600E
Issue Date: 1-Jul-2022
Publisher: Springer
Journal Title: Brain Tumor Pathology
Volume: 39
Issue: 3
Start Page: 162
End Page: 170
Publisher DOI: 10.1007/s10014-022-00432-7
Abstract: The aim of this study was to analyze the clinical and radiological characteristics of glioblastomas (GBMs) harboring a BRAF mutation. Sequencing analysis of BRAF, IDH1/2, and TERT promoters was performed on GBM samples of patients older than 15 years. The clinical, pathological, and radiological data of patients were retrospectively reviewed. Patients were classified into three groups according to their BRAF and IDH1/2 status: BRAF group, IDH group, and BRAF/IDH-wild-type (WT) group. Among 179 GBM cases, we identified nine cases with a BRAF mutation and nine with IDH mutation. The WT group had 161 cases. Age at onset in the BRAF group was significantly lower compared to the WT group and was similar to the IDH group. In cases with negative IDH1-R132H staining and age < 55 years, 15.2% were BRAF-mutant cases. Similar to the IDH group, overall survival of the BRAF group was significantly longer compared with the WT group. Among nine cases in the BRAF group, three cases had hemorrhagic onset and prior lesions were observed in two cases. In conclusion, age < 55 years, being IDH1-R132H negative, with hemorrhagic onset or the presence of prior lesions are factors that signal recommendation of BRAF analysis for adult GBM patients.
Rights: This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at:
Type: article (author version)
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 伊師 雪友

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