| Title: | Clinical and radiological findings of glioblastomas harboring a BRAF V600E mutation |
| Authors: | Ishi, Yukitomo Browse this author →KAKEN DB |
| Yamaguchi, Shigeru Browse this author |
| Okamoto, Michinari Browse this author |
| Sawaya, Ryosuke Browse this author |
| Endo, Shogo Browse this author |
| Motegi, Hiroaki Browse this author |
| Terasaka, Shunsuke Browse this author |
| Tanei, Zen-ichi Browse this author |
| Hatanaka, Kanako C. Browse this author |
| Tanaka, Shinya Browse this author →KAKEN DB |
| Fujimura, Miki Browse this author →KAKEN DB |
| Keywords: | BRAF V600E |
| Glioblastoma |
| IDH1 |
| 2 |
| MRI |
| Issue Date: | 1-Jul-2022 |
| Publisher: | Springer |
| Journal Title: | Brain Tumor Pathology |
| Volume: | 39 |
| Issue: | 3 |
| Start Page: | 162 |
| End Page: | 170 |
| Publisher DOI: | 10.1007/s10014-022-00432-7 |
| Abstract: | The aim of this study was to analyze the clinical and radiological characteristics of glioblastomas (GBMs) harboring a BRAF mutation. Sequencing analysis of BRAF, IDH1/2, and TERT promoters was performed on GBM samples of patients older than 15 years. The clinical, pathological, and radiological data of patients were retrospectively reviewed. Patients were classified into three groups according to their BRAF and IDH1/2 status: BRAF group, IDH group, and BRAF/IDH-wild-type (WT) group. Among 179 GBM cases, we identified nine cases with a BRAF mutation and nine with IDH mutation. The WT group had 161 cases. Age at onset in the BRAF group was significantly lower compared to the WT group and was similar to the IDH group. In cases with negative IDH1-R132H staining and age < 55 years, 15.2% were BRAF-mutant cases. Similar to the IDH group, overall survival of the BRAF group was significantly longer compared with the WT group. Among nine cases in the BRAF group, three cases had hemorrhagic onset and prior lesions were observed in two cases. In conclusion, age < 55 years, being IDH1-R132H negative, with hemorrhagic onset or the presence of prior lesions are factors that signal recommendation of BRAF analysis for adult GBM patients. |
| Rights: | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10014-022-00432-7 |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/90105 |
| Appears in Collections: | 医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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