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Genital organ-associated lymphoid tissues arranged in a ring in the mucosa of cow vaginal vestibules

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Title: Genital organ-associated lymphoid tissues arranged in a ring in the mucosa of cow vaginal vestibules
Authors: Chuluunbaatar, Tsolmon Browse this author
Ichii, Osamu Browse this author
Masum, Md Abdul Browse this author
Namba, Takashi Browse this author
Islam, Md Rashedul Browse this author
Otani, Yuki Browse this author
Elewa, Yaser Hosny Ali Browse this author
Kon, Yasuhiro Browse this author →KAKEN DB
Keywords: Cow
Genital organ associated lymphoid tissue
Lymphoid ring
Lymphatic follicle
Diffuse lymphoid tissue
Issue Date: Jul-2022
Publisher: Elsevier
Journal Title: Research in veterinary science
Volume: 145
Start Page: 147
End Page: 158
Publisher DOI: 10.1016/j.rvsc.2022.02.011
Abstract: Female reproductive tracts are equipped with local and mucosal immune systems; however, structural information remains unclear for farm animals. In this study, the mucosa-associated lymphoid tissue-like structures in cow reproductive tracts were described. Vaginal vestibule (VV) and external parts of the genital organ, including the clitoris and vulva, were morphologically analyzed. Whole-mount specimens revealed several hematoxylinpositive spots arranged in a ring in the mucosa. Histologically, these spots were aggregated immune cells and defined as genital organ-associated lymphoid tissues (GOALTs). GOALTs were composed of lymphatic follicles (LFs) or diffuse lymphoid tissues (DLTs) at different depths of lamina propria. LFs frequently contained germinal centers. Scattered lymphocytes occupied the border area between follicles and epithelium, whereas DLTs had indefinite shapes. GOALTs contained immune cells and high endothelial venules. B cells were dominant both in LFs and DLTs. Abundant collagenous fibers were stretched across VV lamina propria, whereas reticular fibers were primarily observed in the DLT rather than LF. The epithelium covering of GOALTs was partially or fully disrupted by the invasion of immune cells toward the VV lumen. These findings suggest GOALTs function as a "genital lymphoid ring" as in Waldeyer's pharyngeal ring and act as immunological gate systems in cow reproductive tracts.
Rights: © 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 昆 泰寛

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