|
Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine >
Peer-reviewed Journal Articles, etc >
Genital organ-associated lymphoid tissues arranged in a ring in the mucosa of cow vaginal vestibules
This item is licensed under:Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
| Title: | Genital organ-associated lymphoid tissues arranged in a ring in the mucosa of cow vaginal vestibules |
| Authors: | Chuluunbaatar, Tsolmon Browse this author | | Ichii, Osamu Browse this author | | Masum, Md Abdul Browse this author | | Namba, Takashi Browse this author | | Islam, Md Rashedul Browse this author | | Otani, Yuki Browse this author | | Elewa, Yaser Hosny Ali Browse this author | | Kon, Yasuhiro Browse this author →KAKEN DB |
| Keywords: | Cow | | Genital organ associated lymphoid tissue | | Lymphoid ring | | Lymphatic follicle | | Diffuse lymphoid tissue |
| Issue Date: | Jul-2022 |
| Publisher: | Elsevier |
| Journal Title: | Research in veterinary science |
| Volume: | 145 |
| Start Page: | 147 |
| End Page: | 158 |
| Publisher DOI: | 10.1016/j.rvsc.2022.02.011 |
| Abstract: | Female reproductive tracts are equipped with local and mucosal immune systems; however, structural information remains unclear for farm animals. In this study, the mucosa-associated lymphoid tissue-like structures in cow reproductive tracts were described. Vaginal vestibule (VV) and external parts of the genital organ, including the clitoris and vulva, were morphologically analyzed. Whole-mount specimens revealed several hematoxylinpositive spots arranged in a ring in the mucosa. Histologically, these spots were aggregated immune cells and defined as genital organ-associated lymphoid tissues (GOALTs). GOALTs were composed of lymphatic follicles (LFs) or diffuse lymphoid tissues (DLTs) at different depths of lamina propria. LFs frequently contained germinal centers. Scattered lymphocytes occupied the border area between follicles and epithelium, whereas DLTs had indefinite shapes. GOALTs contained immune cells and high endothelial venules. B cells were dominant both in LFs and DLTs. Abundant collagenous fibers were stretched across VV lamina propria, whereas reticular fibers were primarily observed in the DLT rather than LF. The epithelium covering of GOALTs was partially or fully disrupted by the invasion of immune cells toward the VV lumen. These findings suggest GOALTs function as a "genital lymphoid ring" as in Waldeyer's pharyngeal ring and act as immunological gate systems in cow reproductive tracts. |
| Rights: | © 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ | | https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/90205 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
|
Submitter: 昆 泰寛
|
