Simple and validated method to quantify lacosamide in human breast milk and plasma using UPLC/MS/MS and its application to estimate drug transfer into breast milk.


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Title:	Simple and validated method to quantify lacosamide in human breast milk and plasma using UPLC/MS/MS and its application to estimate drug transfer into breast milk.
Authors:	Furugen, Ayako Browse this author →KAKEN DB
	Nishimura, Ayako Browse this author
	Umazume, Takeshi Browse this author →KAKEN DB
	Ishikawa, Hina Browse this author
	Narumi, Katsuya Browse this author →KAKEN DB
	Kobayashi, Masaki Browse this author →KAKEN DB
Keywords:	Breast milk
	Lacosamide
	Milk to plasma ratio
	Relative infant dose
	UPLC/MS/MS
Issue Date:	1-Sep-2023
Publisher:	BioMed Central
Journal Title:	Journal of pharmaceutical health care and sciences
Volume:	9
Start Page:	26
Publisher DOI:	10.1186/s40780-023-00295-w
PMID:	37653499
Abstract:	Epilepsy is a common neurological disorder. Lacosamide is a third-generation antiepileptic drug used to treat partial-onset seizures. Limited information is currently available on the transfer of lacosamide to breast milk. To facilitate studies on the safety of lacosamide use during breastfeeding, we aimed to develop a method to quantify lacosamide in human breast milk and plasma using ultra-performance liquid chromatography/tandem mass spectrometry.
Rights:	http://creativecommons.org/licenses/by/4.0/
Type:	article
URI:	http://hdl.handle.net/2115/90569
Appears in Collections:	薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 古堅彩子

OAI-PMH ( junii2 , jpcoar_1.0 )

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