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Detailed analysis of failure patterns using deformable image registration in hypopharyngeal cancer patients treated with sequential boost intensity-modulated radiotherapy
| Title: | Detailed analysis of failure patterns using deformable image registration in hypopharyngeal cancer patients treated with sequential boost intensity-modulated radiotherapy |
| Authors: | Otsuka, Manami Browse this author | | Yasuda, Koichi Browse this author →KAKEN DB | | Uchinami, Yusuke Browse this author | | Tsushima, Nayuta Browse this author | | Suzuki, Takayoshi Browse this author | | Kano, Satoshi Browse this author | | Suzuki, Ryusuke Browse this author | | Miyamoto, Naoki Browse this author | | Minatogawa, Hideki Browse this author | | Dekura, Yasuhiro Browse this author | | Mori, Takashi Browse this author | | Nishioka, Kentaro Browse this author | | Taguchi, Jun Browse this author | | Shimizu, Yasushi Browse this author | | Katoh, Norio Browse this author →KAKEN DB | | Homma, Akihiro Browse this author →KAKEN DB | | Aoyama, Hidefumi Browse this author →KAKEN DB |
| Keywords: | head and neck | | radiation oncology |
| Issue Date: | Feb-2023 |
| Publisher: | John Wiley & Sons |
| Journal Title: | Journal of Medical Imaging and Radiation Oncology |
| Volume: | 67 |
| Issue: | 1 |
| Start Page: | 98 |
| End Page: | 110 |
| Publisher DOI: | 10.1111/1754-9485.13491 |
| Abstract: | Introduction Sequential boost intensity-modulated radiotherapy (SQB-IMRT) uses two different planning CTs (pCTs) and treatment plans. SQB-IMRT is a form of adaptive radiotherapy that allows for responses to changes in the shape of the tumour and organs at risk (OAR). On the other hand, dose accumulation with the two plans can be difficult to evaluate. The purpose of this study was to analyse patterns of loco-regional failure using deformable image registration (DIR) in hypopharyngeal cancer patients treated with SQB-IMRT. Methods Between 2013 and 2019, 102 patients with hypopharyngeal cancer were treated with definitive SQB-IMRT at our institution. Dose accumulation with the 1st and 2nd plans was performed, and the dose to the loco-regional recurrent tumour volume was calculated using the DIR workflow. Failure was classified as follows: (i) in-field (>= 95% of the recurrent tumour volume received 95% of the prescribed dose); (ii) marginal (20-95%); or (iii) out-of-field (<20%). Results After a median follow-up period of 25 months, loco-regional failure occurred in 34 patients. Dose-volume histogram analysis showed that all loco-regional failures occurred in the field within 95% of the prescribed dose, with no marginal or out-of-field recurrences observed. Conclusion The dosimetric analysis using DIR showed that all loco-regional failures were within the high-dose region. More aggressive treatment may be required for gross tumours. |
| Rights: | This is the peer reviewed version of the following article: Otsuka,M.,Yasuda,K.,Uchinami,Y.,Tsushima,N.,Suzuki,T.,Kano,S,Suzuki,R.,Miyamoto,N.,Minatogawa,H.,Dekura,Y.,Mori,T., Nishioka,K., Taguchi,J.,Shimizu,Y.,Katoh,N.,Homma,A.and Aoyama,H. (2023), Detailed analysis of failure patterns using deformable image registration in hypopharyngeal cancer patients treated with sequential boost intensity-modulated radiotherapy. J Med Imaging Radiat Oncol, 67: 98-110, which has been published in final form at 10.1111/1754-9485.13491. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/91127 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 安田 耕一
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