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Regulatory mechanism of heat-active retrotransposons by the SET domain protein SUVH2

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Title: Regulatory mechanism of heat-active retrotransposons by the SET domain protein SUVH2
Authors: Niu, Xiaoying Browse this author
Ge, Zhiyu Browse this author
Ito, Hidetaka Browse this author →KAKEN DB
Keywords: epigenetics
environmental stress
Arabidopsis thaliana
Issue Date: 8-Feb-2024
Publisher: Frontiers
Journal Title: Frontiers in Plant Science
Volume: 15
Start Page: 1355626
Publisher DOI: 10.3389/fpls.2024.1355626
Abstract: New transposon insertions are deleterious to genome stability. The RNA-directed DNA methylation (RdDM) pathway evolved to regulate transposon activity via DNA methylation. However, current studies have not yet clearly described the transposition regulation. ONSEN is a heat-activated retrotransposon that is activated at 37°C. The plant-specific SUPPRESSOR OF VARIEGATION 3–9 HOMOLOG (SUVH) family proteins function downstream of the RdDM pathway. The SUVH protein families are linked to TE silencing by two pathways, one through DNA methylation and the other through chromatin remodeling. In this study, we analyzed the regulation of ONSEN activity by SUVH2. We observed that ONSEN transcripts were increased; however, there was no transpositional activity in Arabidopsis suvh2 mutant. The suvh2 mutant produced siRNAs from the ONSEN locus under heat stress, suggesting that siRNAs are involved in suppressing transposition. These results provide new insights into the regulatory mechanisms of retrotransposons that involve siRNA in the RdDM pathway.
Type: article
Appears in Collections:理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 伊藤 秀臣

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