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Rose bengal-decorated rice husk-derived silica nanoparticles enhanced singlet oxygen generation for antimicrobial photodynamic inactivation
| Title: | Rose bengal-decorated rice husk-derived silica nanoparticles enhanced singlet oxygen generation for antimicrobial photodynamic inactivation |
| Authors: | Mori, Nanase Browse this author | | Kawasaki, Hideya Browse this author →KAKEN DB | | Nishida, Erika Browse this author →KAKEN DB | | Kanemoto, Yukimi Browse this author →KAKEN DB | | Miyaji, Hirofumi Browse this author →KAKEN DB | | Umeda, Junko Browse this author →KAKEN DB | | Kondoh, Katsuyoshi Browse this author →KAKEN DB |
| Keywords: | rice husk | | silica | | rose bengal | | photosensitizer | | singlet oxygen | | photodynamic therapy |
| Issue Date: | 25-Jan-2023 |
| Publisher: | Springer |
| Journal Title: | Journal of Materials Science |
| Volume: | 58 |
| Issue: | 6 |
| Start Page: | 2801 |
| End Page: | 2813 |
| Publisher DOI: | 10.1007/s10853-023-08194-z |
| PMID: | 36713647 |
| Abstract: | Rice husks (RHs) are well known for their high silica content, and the RH-derived silica nanoparticles (RH NPs) are amorphous and biocompatible; therefore, they are suitable raw materials for biomedical applications. In this study, rose bengal-impregnated rice husk nanoparticles (RB-RH NPs) were prepared for their potential photosensitization and 1O2 generation as antimicrobial photodynamic inactivation. RB is a halogen-xanthene type's PS showing high singlet oxygen efficiency, and the superior photophysical properties are desirable for RB in the antimicrobial photodynamic inactivation of bacteria. To enhance the binding of anionic RB to RH NPs, we conducted cationization for the RH NPs using polyethyleneimine (PEI). The control of the RB adsorption state on cationic PEI-modified RH NPs was essential for RB RH-NP photosensitizers to obtain efficient 1O2 generation. Minimizing RB aggregation allowed highly efficient 1O2 production from RB-RH NPs at the molar ratio of RB with the PEI, XRB/PEI. =0.1. The RB-RH NPs have significant antimicrobial activity against S. mutants compared to free RB after white light irradiation. The RB-RH NP-based antimicrobial photodynamic inactivation can be employed effectively in treating S. mutants for dental applications. |
| Rights: | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s10853-023-08194-z |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/92681 |
| Appears in Collections: | 歯学院・歯学研究院 (Graduate School of Dental Medicine / Faculty of Dental Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 宮治 裕史
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