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Asymmetric synthesis of a diastereomer of the structure proposed for amphidinolide A and the determination of its absolute configuration

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Title: Asymmetric synthesis of a diastereomer of the structure proposed for amphidinolide A and the determination of its absolute configuration
Authors: Ishiyama, Haruaki Browse this author
Nakamura, Yoichi Browse this author
Kobayashi, Jun'ichi3 Browse this author →KAKEN DB
Authors(alt): 小林, 淳一3
Keywords: Amphidinium sp
Macrolide
Amphidinolide A
Absolute configuration
Issue Date: 25-Oct-2005
Publisher: Elsevier Ltd
Journal Title: Tetrahedron
Volume: 62
Issue: 1
Start Page: 166
End Page: 170
Publisher DOI: 10.1016/j.tet.2005.09.120
Abstract: An asymmetric synthesis of a diastereomer (2) of the structure (1) proposed for amphidinolide A, a cytotoxic macrolide from the cultured dinoflagellate Amphidinium sp., has been accomplished. The absolute configuration of amphidinolide A was established as 3 from comparison of NMR data, HPLC analysis, and [α]D values of amphidinolide A, and comparison with the synthetic diastereomers 2 and 3, the latter of which was synthesized previously by Trost's group.
Relation: http://www.sciencedirect.com/science/journal/00404020
Type: article (author version)
URI: http://hdl.handle.net/2115/996
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 小林 淳一

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