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Asymmetric synthesis of a diastereomer of the structure proposed for amphidinolide A and the determination of its absolute configuration
Title: | Asymmetric synthesis of a diastereomer of the structure proposed for amphidinolide A and the determination of its absolute configuration |
Authors: | Ishiyama, Haruaki Browse this author | Nakamura, Yoichi Browse this author | Kobayashi, Jun'ichi3 Browse this author →KAKEN DB |
Authors(alt): | 小林, 淳一3 |
Keywords: | Amphidinium sp | Macrolide | Amphidinolide A | Absolute configuration |
Issue Date: | 25-Oct-2005 |
Publisher: | Elsevier Ltd |
Journal Title: | Tetrahedron |
Volume: | 62 |
Issue: | 1 |
Start Page: | 166 |
End Page: | 170 |
Publisher DOI: | 10.1016/j.tet.2005.09.120 |
Abstract: | An asymmetric synthesis of a diastereomer (2) of the structure (1) proposed for amphidinolide A, a cytotoxic macrolide from the cultured dinoflagellate Amphidinium sp., has been accomplished. The absolute configuration of amphidinolide A was established as 3 from comparison of NMR data, HPLC analysis, and [α]D values of amphidinolide A, and comparison with the synthetic diastereomers 2 and 3, the latter of which was synthesized previously by Trost's group. |
Relation: | http://www.sciencedirect.com/science/journal/00404020 |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/996 |
Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 小林 淳一
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