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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Engineering / Faculty of Engineering >
Peer-reviewed Journal Articles, etc >
Drastic change of local stiffness distribution correlating to cell migration in living fibroblasts.
| Title: | Drastic change of local stiffness distribution correlating to cell migration in living fibroblasts. |
| Authors: | Nagayama, Masafumi Browse this author →KAKEN DB | | Haga, Hisashi Browse this author →KAKEN DB | | Kawabata, Kazushige Browse this author |
| Keywords: | scanning probe microscopy | | force modulation mode | | actin filaments | | NIH3T3 | | cell movement |
| Issue Date: | Dec-2001 |
| Citation: | Wiley-Liss, Inc. |
| Journal Title: | Cell Motility and the Cytoskeleton |
| Volume: | 50 |
| Issue: | 4 |
| Start Page: | 173 |
| End Page: | 179 |
| Publisher DOI: | 10.1002/cm.10008 |
| PMID: | 11807938 |
| Abstract: | Sequential images of the local stiffness distribution of living fibroblasts (NIH3T3) were captured under a culture condition using scanning probe microscopy in a force modulation mode. We found a clear relation between cell migration and local stiffness distribution on the cell: When cells were stationary at one position, the stiffness distribution of their cellular surface was quite stable. On the other hand, once the cells started to move, the stiffness in their nuclear regions drastically decreased. Possible explanations for the correlation between the cell migration and the cell stiffness are proposed. Cell Motil. Cytoskeleton 50:173-179, 2001. © 2001 Wiley-Liss, Inc. |
| Rights: | Copyright © 2001 John Wiley & Sons, Inc., Cell Motility and the Cytoskeleton, volume 50, issue 4, pp. 173-179 |
| Relation: | http://www.interscience.wiley.com/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/17124 |
| Appears in Collections: | 工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 永山 昌史
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