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Drastic change of local stiffness distribution correlating to cell migration in living fibroblasts.

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Title: Drastic change of local stiffness distribution correlating to cell migration in living fibroblasts.
Authors: Nagayama, Masafumi Browse this author →KAKEN DB
Haga, Hisashi Browse this author →KAKEN DB
Kawabata, Kazushige Browse this author
Keywords: scanning probe microscopy
force modulation mode
actin filaments
cell movement
Issue Date: Dec-2001
Citation: Wiley-Liss, Inc.
Journal Title: Cell Motility and the Cytoskeleton
Volume: 50
Issue: 4
Start Page: 173
End Page: 179
Publisher DOI: 10.1002/cm.10008
PMID: 11807938
Abstract: Sequential images of the local stiffness distribution of living fibroblasts (NIH3T3) were captured under a culture condition using scanning probe microscopy in a force modulation mode. We found a clear relation between cell migration and local stiffness distribution on the cell: When cells were stationary at one position, the stiffness distribution of their cellular surface was quite stable. On the other hand, once the cells started to move, the stiffness in their nuclear regions drastically decreased. Possible explanations for the correlation between the cell migration and the cell stiffness are proposed. Cell Motil. Cytoskeleton 50:173-179, 2001. © 2001 Wiley-Liss, Inc.
Rights: Copyright © 2001 John Wiley & Sons, Inc., Cell Motility and the Cytoskeleton, volume 50, issue 4, pp. 173-179
Type: article (author version)
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 永山 昌史

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