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Drastic change of local stiffness distribution correlating to cell migration in living fibroblasts.

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タイトル: Drastic change of local stiffness distribution correlating to cell migration in living fibroblasts.
著者: Nagayama, Masafumi 著作を一覧する
Haga, Hisashi 著作を一覧する
Kawabata, Kazushige 著作を一覧する
キーワード: scanning probe microscopy
force modulation mode
actin filaments
NIH3T3
cell movement
発行日: 2001年12月
引用: Wiley-Liss, Inc.
誌名: Cell Motility and the Cytoskeleton
巻: 50
号: 4
開始ページ: 173
終了ページ: 179
出版社 DOI: 10.1002/cm.10008
抄録: Sequential images of the local stiffness distribution of living fibroblasts (NIH3T3) were captured under a culture condition using scanning probe microscopy in a force modulation mode. We found a clear relation between cell migration and local stiffness distribution on the cell: When cells were stationary at one position, the stiffness distribution of their cellular surface was quite stable. On the other hand, once the cells started to move, the stiffness in their nuclear regions drastically decreased. Possible explanations for the correlation between the cell migration and the cell stiffness are proposed. Cell Motil. Cytoskeleton 50:173-179, 2001. © 2001 Wiley-Liss, Inc.
Rights: Copyright © 2001 John Wiley & Sons, Inc., Cell Motility and the Cytoskeleton, volume 50, issue 4, pp. 173-179
Relation (URI): http://www.interscience.wiley.com/
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/17124
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 永山 昌史

 

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