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A unimolecular nanocapsule : Encapsulation property of amphiphilic polymer based on hyperbranched polythreitol

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Title: A unimolecular nanocapsule : Encapsulation property of amphiphilic polymer based on hyperbranched polythreitol
Authors: Kitajyo, Yoshikazu Browse this author
Nawa, Yumiko Browse this author
Tamaki, Masaki Browse this author
Tani, Hirofumi Browse this author →KAKEN DB
Takahashi, Kenji Browse this author
Kaga, Harumi Browse this author
Satoh, Toshifumi Browse this author →KAKEN DB
Kakuchi, Toyoji Browse this author
Keywords: Amphiphiles
Core–shell polymers
Issue Date: 27-Jul-2007
Publisher: Elsevier Ltd.
Journal Title: Polymer
Volume: 48
Issue: 16
Start Page: 4683
End Page: 4690
Publisher DOI: 10.1016/j.polymer.2007.06.026
Abstract: Hyperbranched polythreitol (1) with different molecular weights (Mw,SLS: 1.18 × 10 4 and 4.79 × 10 4) was reacted with trityl chloride in DMF to afford a novel amphiphilic polymer (2) consisting of 1 as the hydrophilic core and the trityl groups as the hydrophobic shell. Compound 2 was tested for its ability to act as a unimolecular nanocapsule toward the water-soluble dye, rose bengal (RB). Their encapsulation and release properties were also evaluated by comparison with the degree of substitution (DS) of the trityl groups, i.e., the hydrophobic shell density. The polymers were found to have very good unimolecular nanocapsule characteristics even at extremely low concentrations. The average number of RBs per polymer molecule depended on the hydrophilic core size and the hydrophobic shell density. The increasing DS value led to a decrease in the encapsulated amount due to the decrease in the hydrophilic core space, while the low DS value (less than ca. 20 mol%) led to a destabilization as a unimolecular nanocapsule and a lower encapsulation ability. In particular, 2 with ca. 23% DS value showed an efficient encapsulation. Based on a release test of the RB-loaded unimolecular nanocapsules, the polymers showed a high RB-holding ability in water.
Type: article (author version)
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 佐藤 敏文

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