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Title: 温泉療法と血小板グルタチオン代謝
Other Titles: Balneotherapy and Platelet Glutathione Metabolism
Authors: 大塚, 吉則1 Browse this author →KAKEN DB
薮中, 宗之2 Browse this author
野呂, 浩史3 Browse this author
渡辺, 一郎4 Browse this author
阿岸, 祐幸5 Browse this author
Authors(alt): Ohtsuka, Yoshinori1
Yabunaka, Noriyuki2
Noro, Hiroshi3
Watanabe, Ichiro4
Agishi, Yuko5
Keywords: Balneotherapy
Thermal stress
Platelet glutathione metabolism
Diabetes mellitus
Platelet aggregability
Issue Date: Feb-1996
Publisher: 日本温泉気候物理医学会
Journal Title: 日本温泉気候物理医学会雑誌
Volume: 59
Issue: 2
Start Page: 83
End Page: 88
Abstract: Two experiments were performed to clarify the effects of balneotherapy on platelet glutathione metabolism. One experiment, in which healthy men were subjected to water immersion at temperatures of 25℃, 36℃, and 42℃ for 10 min, showed that the level of platelet lipid peroxides (LPO) tended to increase at 25℃ and 42℃, suggesting the presence of oxidative stress at these temperatures. When an antioxidative defense system was induced at these temperatures, the levels of platelet glutathione (GSH), glutathione peroxidase (GPX) and glutathione reductase (GR) activities increased. The other experiment, in which 4 weeks of balneotherapy was applied to type II (non-insulin-dependent) diabetic patients, showed that the level of GSH on admission correlated well with that of fasting plasma glucose (FPG, r=0.692, p<O.050). After 4 weeks of balneotherpy, the level of GSH increased (p<O.01) in well-controlled patients (FPG<150 mg/dl) and decreased (p<0.05) in poorly controlled patients (FPG≧150 mg/dl). There was a negative correlation between GPX activities and the level of FPG (r=-0.430, p<0.05). After the balneotherapy, the activity increased in five patients, decreased in three patients, and showed no changes in four patients. These results indicate that, in diabetic patients, 1) platelet GSH synthesis is obviously induced in response to oxidative stress, 2) lowered GPX activities suggest an impaired antioxidative defense system, and 3) platelet glutathione metabolism was partly improved by 4 weeks of balneotherapy but depended on the control status of plasma glucose levels. From these findings, we conclude that 1) patients whose platelet antioxidative defense system is damaged such as those with diabetes mellitus should not take hot or cold bath, and that 2) balneotherapy improves platelet glutathione metabolism, leading to normalization of platelet aggregability.
Type: article
Appears in Collections:教育学院・教育学研究院 (Graduate School of Education / Faculty of Education) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 大塚 吉則

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