HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
教育学院・教育学研究院  >
雑誌発表論文等  >

温泉入浴が尿酸排泄に及ぼす影響について

フルテキスト
NOKB67-2_79-86.pdf823.74 kBPDF見る/開く
この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/44061

タイトル: 温泉入浴が尿酸排泄に及ぼす影響について
その他のタイトル: Uric Acid Excretion after Bathing in Hot Spring Water
著者: 高橋, 伸彦 著作を一覧する
大塚, 吉則 著作を一覧する
キーワード: Uric acid
ORP
pH
bath
hot spring
発行日: 2004年 2月 1日
出版者: 日本温泉気候物理医学会
誌名: 日本温泉気候物理医学会雑誌
巻: 67
号: 2
開始ページ: 79
終了ページ: 86
抄録: Purpose: It has been reported that the excretion of urinary uric acid is increased by the ingestion of bicarbonated salt spring water or bathing in radioactive spring water. Furthermore, uric acid is considered to play an important role in diminishing oxidative stresses. We therefore investigated the influence of bathing water on the excretion of uric acid from the aspect of urinary oxidation-reduction potential (ORP). Methods: 1. Nine volunteers (three males and six females) aged 22 to 26 were divided into three bathing groups: in sulphur spring water, in bicarbonated salt spring water, and in tap water. Urine specimens were taken six times from 0600 to 1600 while repeating bathing and taking meals alternatively at intervals of 2 hours. ORP, pH, and the concentrations of uric acid and creatinine in urine specimens were measured. 2. ORP, pH, and the concentrations of uric acid and creatinine were measured in the urine specimens taken from the seven subjects in the bicarbonated salt spring and sulphur spring bathing groups early in the morning everyday during the stay at the spa. In addition, serum uric acid levels were measured at the beginning and the end of the stay. Results: 1. The average ORP was 527 mV in tap water, 407 mV in bicarbonated salt spring, and 145 mV in sulphur spring bathing. The urinary ORP increased obviously after bathing in tap water and decreased after bathing in sulfur spring water. The average urinary ORP was 257 mV after bathing in tap water, 220 mV after bathing in bicarbonated salt spring water, and 216 mV after bathing in sulfur spring water. Urinary uric acid/creatinine ratio showed a significant and negative correlation with urinary ORP in all three kinds of water. Urinary pH after bathing varied randomly. Urinary uric acid/creatinine ratio exhibited a significant positive correlation with the urinary pH in all three kinds of water. 2. While serum uric acid elevated after a short stay at the spa of less than 10 days, it decreased after a long stay of more than 2 weeks. Discussion and Conclusions: Urinary ORP immediately reflected the ORP of bathing water. The urinary uric acid / creatinine ratio possessed a negative correlation with urinary ORP. Because the ORP of spring water is commonly lower than that of tap water, bathing in spring water may increase the excretion of uric acid and as a result, may lower the serum uric acid levels after the long stay at the spa. The urinary uric acid/creatinine ratio exhibited a significant positive correlation with urinary pH. The results suggest that if the urinary pH gradually becomes alkaline after a long period of ingestion of alkaline spring water, the excretion of uric acid will be promoted, resulting in a lowered serum uric acid.
資料タイプ: article
URI: http://hdl.handle.net/2115/44061
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 大塚 吉則

 

本サイトに関するご意見・お問い合わせは repo at lib.hokudai.ac.jp へお願いします。 - 北海道大学