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Regioselective Synthesis of Trifluoromethyl Group Substituted Pyrazole Derivatives from 1-Aryl-3,4,4,4-tetrafluoro-2-buten-1-ones
| Title: | Regioselective Synthesis of Trifluoromethyl Group Substituted Pyrazole Derivatives from 1-Aryl-3,4,4,4-tetrafluoro-2-buten-1-ones |
| Authors: | Sano, Keisuke Browse this author | | Hara, Shoji Browse this author |
| Keywords: | Trifluoromethylpyrazole | | Tetrafluoro-2-buten-1-one | | Regioselective Reaction | | Celecoxib | | Hydrazine |
| Issue Date: | 1-Jan-2010 |
| Publisher: | Japan Institute of Heterocyclic Chemistry |
| Journal Title: | Heterocycles |
| Volume: | 80 |
| Issue: | 1 |
| Start Page: | 349 |
| End Page: | 357 |
| Publisher DOI: | 10.3987/COM-09-S(S)26 |
| Abstract: | Trifluoromethyl group substituted pyrazole derivatives were prepared from hydrazines and 1-aryl-3,4,4,4-tetrafluoro-2-buten-1-ones obtained by the deoxyfluorination of β-diketones. The reaction proceeded regioselectively and 5-aryl-3-trifluoromethyl-1-phenyl-1H-pyrazole was obtained from phenylhydrazine. On the other hand, when methylhydrazine was used, 3-aryl-5-trifluoromethyl-1-methyl-1H-pyrazole was selectively formed. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/45015 |
| Appears in Collections: | 工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 原 正治
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