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Synthesis of Cyclic ADP-Carbocylcic-Xylose and its 3′′-OO-Methyl Analogue as Stable and Potent Ca2+-Mobilizing Agents

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Title: Synthesis of Cyclic ADP-Carbocylcic-Xylose and its 3′′-OO-Methyl Analogue as Stable and Potent Ca2+-Mobilizing Agents
Authors: Kudoh, Takashi Browse this author
Matsuda, Akira Browse this author
Shuto, Satoshi Browse this author
Murayama, Takashi Browse this author
Ogawa, Yasuo Browse this author
Issue Date: Apr-2006
Publisher: Taylor & Francis
Journal Title: Nucleosides, Nucleotides and Nucleic Acids
Volume: 25
Issue: 4-6
Start Page: 583
End Page: 599
Publisher DOI: 10.1080/15257770600685867
PMID: 16838847
Abstract: We previously showed that 3”-deoxy-cyclic ADP-carbocyclic-ribose (3”-deoxy-cADPcR, 2) is a stable and highly potent analogue of cyclic ADP-ribose (cADPR, 1), a Ca2+-mobilizing second messenger. From these results, we newly designed another 3”-modified analogues of cADPcR and identified the N1-“xylo”-type carbocyclic analogue, i.e., cADPcX (4), as one of the most potent cADPR-related compounds reported so far.
Rights: This is an electronic version of an article published in Nucleosides, Nucleotides & Nucleic Acids, 25(4/6), 583-599, 2006. Nucleosides, Nucleotides & Nucleic Acids is available online at: http://www.informaworld.com/openurl?genre=article&issn=15257770&volume=25&issue=4-6&spage=583
Type: article (author version)
URI: http://hdl.handle.net/2115/46970
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 松田 彰

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