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Synthesis of Cyclic ADP-Carbocylcic-Xylose and its 3′′-OO-Methyl Analogue as Stable and Potent Ca2+-Mobilizing Agents
Title: | Synthesis of Cyclic ADP-Carbocylcic-Xylose and its 3′′-OO-Methyl Analogue as Stable and Potent Ca2+-Mobilizing Agents |
Authors: | Kudoh, Takashi Browse this author | Matsuda, Akira Browse this author | Shuto, Satoshi Browse this author | Murayama, Takashi Browse this author | Ogawa, Yasuo Browse this author |
Issue Date: | Apr-2006 |
Publisher: | Taylor & Francis |
Journal Title: | Nucleosides, Nucleotides and Nucleic Acids |
Volume: | 25 |
Issue: | 4-6 |
Start Page: | 583 |
End Page: | 599 |
Publisher DOI: | 10.1080/15257770600685867 |
PMID: | 16838847 |
Abstract: | We previously showed that 3”-deoxy-cyclic ADP-carbocyclic-ribose (3”-deoxy-cADPcR, 2) is a stable and highly potent analogue of cyclic ADP-ribose (cADPR, 1), a Ca2+-mobilizing second messenger. From these results, we newly designed another 3”-modified analogues of cADPcR and identified the N1-“xylo”-type carbocyclic analogue, i.e., cADPcX (4), as one of the most potent cADPR-related compounds reported so far. |
Rights: | This is an electronic version of an article published in Nucleosides, Nucleotides & Nucleic Acids, 25(4/6), 583-599, 2006. Nucleosides, Nucleotides & Nucleic Acids is available online at: http://www.informaworld.com/openurl?genre=article&issn=15257770&volume=25&issue=4-6&spage=583 |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/46970 |
Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 松田 彰
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