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Reduced Plasma Glucose by Asparagine Synthetase Knockdown in the Mouse Liver

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Title: Reduced Plasma Glucose by Asparagine Synthetase Knockdown in the Mouse Liver
Authors: Iida, Shinya Browse this author
Kamiya, Hiroyuki Browse this author →KAKEN DB
Nakaya, Akihiro Browse this author →KAKEN DB
Hayashi, Yasuhiro Browse this author →KAKEN DB
Sawada, Akihiro Browse this author
Kaji, Noritada Browse this author →KAKEN DB
Baba, Yoshinobu Browse this author →KAKEN DB
Harashima, Hideyoshi Browse this author →KAKEN DB
Keywords: asparagine synthetase
small interfering RNA
plasma glucose
Issue Date: Dec-2013
Publisher: Pharmaceutical soc japan
Journal Title: Biological & pharmaceutical bulletin
Volume: 36
Issue: 12
Start Page: 2009
End Page: 2011
Abstract: Expression of the asparagine synthetase gene is dependent on extracellular glucose concentration. This gene was knocked-down in livers of male Balb/c mice by a hydrodynamic tail vein injection of small interfering RNA (siRNA) against the gene. This knockdown resulted in a significant decrease in plasma glucose concentration. These results suggested that asparagine synthetase is a novel protein that regulates plasma glucose levels.
Type: article
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 原島 秀吉

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