Reduced Plasma Glucose by Asparagine Synthetase Knockdown in the Mouse Liver


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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/56589

Title:	Reduced Plasma Glucose by Asparagine Synthetase Knockdown in the Mouse Liver
Authors:	Iida, Shinya Browse this author
	Kamiya, Hiroyuki Browse this author →KAKEN DB
	Nakaya, Akihiro Browse this author →KAKEN DB
	Hayashi, Yasuhiro Browse this author →KAKEN DB
	Sawada, Akihiro Browse this author
	Kaji, Noritada Browse this author →KAKEN DB
	Baba, Yoshinobu Browse this author →KAKEN DB
	Harashima, Hideyoshi Browse this author →KAKEN DB
Keywords:	asparagine synthetase
	small interfering RNA
	plasma glucose
Issue Date:	Dec-2013
Publisher:	Pharmaceutical soc japan
Journal Title:	Biological & pharmaceutical bulletin
Volume:	36
Issue:	12
Start Page:	2009
End Page:	2011
Abstract:	Expression of the asparagine synthetase gene is dependent on extracellular glucose concentration. This gene was knocked-down in livers of male Balb/c mice by a hydrodynamic tail vein injection of small interfering RNA (siRNA) against the gene. This knockdown resulted in a significant decrease in plasma glucose concentration. These results suggested that asparagine synthetase is a novel protein that regulates plasma glucose levels.
Type:	article
URI:	http://hdl.handle.net/2115/56589
Appears in Collections:	薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 原島秀吉

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