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Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Education / Faculty of Education >
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Intravascular Free Tissue Factor Pathway Inhibitor Is Inversely Correlated With HDL Cholesterol and Postheparin Lipoprotein Lipase but Proportional to Apolipoprotein A-II
| Title: | Intravascular Free Tissue Factor Pathway Inhibitor Is Inversely Correlated With HDL Cholesterol and Postheparin Lipoprotein Lipase but Proportional to Apolipoprotein A-II |
| Authors: | Kawaguchi, Akito Browse this author →KAKEN DB | | Miyao, Yuji Browse this author | | Noguchi, Teruo Browse this author | | Nonogi, Hiroshi Browse this author | | Yamagishi, Masakazu Browse this author | | Miyatake, Kunio Browse this author | | Kamikubo, Yuichi Browse this author | | Kumeda, Kousuke Browse this author | | Tsushima, Motoo Browse this author | | Yamamoto, Akira Browse this author | | Kato, Hisao Browse this author |
| Keywords: | TFPI | | HDL cholesterol | | Apolipoprotein A-II | | Lipoprotein lipase (lipoprotein lipase) | | coronary artery disease |
| Issue Date: | Jan-2000 |
| Journal Title: | Arteriosclerosis, thrombosis, and vascular biology |
| Volume: | 20 |
| Issue: | 1 |
| Start Page: | 251 |
| End Page: | 258 |
| Publisher DOI: | 10.1161/01.ATV.20.1.251 |
| PMID: | 10634826 |
| Abstract: | To elucidate the distribution and clinical implications of tissue factor pathway inhibitor (TFPI) concentrations, we measured TFPI levels consisting of preheparin free, lipoprotein-bound (Lp-bound), and endothelial cell-anchor pools in 156 patients with coronary artery disease (average age, 61.2+/-9.1 years; range, 32 to 78 years) by heparin infusion (50 IU/kg) and compared them with the preheparin TFPI levels of 229 healthy subjects (average age, 59. 6+/-9.4 years; range, 41 to 80 years). The patients had lower preheparin free TFPI and lower HDL cholesterol (HDL-C) levels than the healthy subjects with equivalent Lp-bound forms (free TFPI, 15. 9+/-6.5 versus 19.2+/-8.1 ng/mL). In a partial correlation analysis, the preheparin free TFPI levels were shown to be inversely correlated with the HDL-C concentrations in both the patients (r=-0. 454, P<0.001) and the healthy subjects (r=-0.136, P<0.05). As determined by comparison of preheparin and postheparin plasma, the patients generally showed preheparin free TFPI <10%, Lp-bound TFPI at 30%, and endothelial cell-anchor TFPI at 60%. When the patients were divided into 4 categories by their LDL cholesterol (LDL-C, 130 mg/dL) and HDL-C (40 mg/dL) levels to specify their coronary risks, the low-HDL-C groups had significantly increased preheparin and postheparin free TFPI levels and decreased postheparin LPL levels, whereas the high-LDL-C groups showed increased levels of Lp-bound TFPI. In a partial correlation analysis, we found a proportional relation between postheparin free TFPI and apolipoprotein A-II (r=0. 5327) and between HDL-C and LPL (r=0.4906), whereas postheparin free TFPI was inversely correlated with HDL-C (r=-0.4280) and postheparin LPL (r=-0.4791). The inverse relationship between TFPI and LPL suggests that increased free TFPI concentrations as a compensatory response of the endothelium to prevent atherothrombotic processes compete with and displace LPL on endothelial surface, resulting in reduced LPL and low HDL-C. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/57389 |
| Appears in Collections: | 教育学院・教育学研究院 (Graduate School of Education / Faculty of Education) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 河口 明人
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