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Spontaneous regression of small cell lung cancer combined with cancer associated retinopathy
| Title: | Spontaneous regression of small cell lung cancer combined with cancer associated retinopathy |
| Authors: | Kitai, Hidenori Browse this author | | Sakakibara-Konishi, Jun Browse this author →KAKEN DB | | Oizumi, Satoshi Browse this author →KAKEN DB | | Hirohashi, Yoshihiko Browse this author →KAKEN DB | | Saito, Wataru Browse this author | | Kanda, Atsuhiro Browse this author →KAKEN DB | | Sato, Noriyuki Browse this author →KAKEN DB | | Nishimura, Masaharu Browse this author →KAKEN DB |
| Keywords: | Small cell lung cancer | | Cancer associated retinopathy | | Spontaneous regression | | Recoverin | | Cytotoxic T lymphocytes | | Immnologic reaction |
| Issue Date: | Jan-2015 |
| Publisher: | Elsevier Ireland |
| Journal Title: | Lung Cancer |
| Volume: | 87 |
| Issue: | 1 |
| Start Page: | 73 |
| End Page: | 76 |
| Publisher DOI: | 10.1016/j.lungcan.2014.10.015 |
| PMID: | 25468200 |
| Abstract: | Spontaneous regression (SR) is defined as the complete or partial disappearance of disease without anticancer treatments. We report a case of SR of small cell lung cancer (SCLC) combined with cancer associated retinopathy (CAR). A 65-year-old woman was admitted to our hospital to examine abnormal shadows of the lung with visual loss. She was diagnosed with SCLC associated with CAR. Subsequent chest X-ray and CT scan showed partial regression of both primary tumor and lymph node metastasis without anticancer treatment. Recoverin antigen was present on the tumor cells and anti-recoverin antibody was observed in the patient's serum. Activation of recoverin-specific antitumor cytotoxic T lymphocyte (CTL) was observed in this patient. SCLC was considered to reduce spontaneously by the activation of recoverin-specific antitumor CTL. To the best of our knowledge, this is the first report of SR in SCLC combined with CAR. (C) 2014 Elsevier Ireland Ltd. All rights reserved. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/58435 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 榊原 純
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