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Spontaneous regression of small cell lung cancer combined with cancer associated retinopathy

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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/58435

Title: Spontaneous regression of small cell lung cancer combined with cancer associated retinopathy
Authors: Kitai, Hidenori Browse this author
Sakakibara-Konishi, Jun Browse this author →KAKEN DB
Oizumi, Satoshi Browse this author →KAKEN DB
Hirohashi, Yoshihiko Browse this author →KAKEN DB
Saito, Wataru Browse this author
Kanda, Atsuhiro Browse this author →KAKEN DB
Sato, Noriyuki Browse this author →KAKEN DB
Nishimura, Masaharu Browse this author →KAKEN DB
Keywords: Small cell lung cancer
Cancer associated retinopathy
Spontaneous regression
Recoverin
Cytotoxic T lymphocytes
Immnologic reaction
Issue Date: Jan-2015
Publisher: Elsevier Ireland
Journal Title: Lung Cancer
Volume: 87
Issue: 1
Start Page: 73
End Page: 76
Publisher DOI: 10.1016/j.lungcan.2014.10.015
PMID: 25468200
Abstract: Spontaneous regression (SR) is defined as the complete or partial disappearance of disease without anticancer treatments. We report a case of SR of small cell lung cancer (SCLC) combined with cancer associated retinopathy (CAR). A 65-year-old woman was admitted to our hospital to examine abnormal shadows of the lung with visual loss. She was diagnosed with SCLC associated with CAR. Subsequent chest X-ray and CT scan showed partial regression of both primary tumor and lymph node metastasis without anticancer treatment. Recoverin antigen was present on the tumor cells and anti-recoverin antibody was observed in the patient's serum. Activation of recoverin-specific antitumor cytotoxic T lymphocyte (CTL) was observed in this patient. SCLC was considered to reduce spontaneously by the activation of recoverin-specific antitumor CTL. To the best of our knowledge, this is the first report of SR in SCLC combined with CAR. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
Type: article (author version)
URI: http://hdl.handle.net/2115/58435
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 榊原 純

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