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Characterization of the human TCAM1P pseudogene and its activation by a potential dual promoter-enhancer: Comparison with a protein-coding mouse orthologue
| Title: | Characterization of the human TCAM1P pseudogene and its activation by a potential dual promoter-enhancer: Comparison with a protein-coding mouse orthologue |
| Authors: | Kurihara, Misuzu Browse this author | | Kimura, Atsushi P. Browse this author →KAKEN DB |
| Keywords: | Dual promoter-enhancer | | Human | | Long non-coding RNA | | Unitary pseudogene | | TCAM1P | | Testis |
| Issue Date: | 13-Feb-2015 |
| Publisher: | Elsevier |
| Journal Title: | FEBS Letters |
| Volume: | 589 |
| Issue: | 4 |
| Start Page: | 540 |
| End Page: | 547 |
| Publisher DOI: | 10.1016/j.febslet.2015.01.023 |
| PMID: | 25622893 |
| Abstract: | TCAM1P is a unitary pseudogene, which was disabled since the human-mouse divergence. Here we found that TCAM1P was specifically expressed in the human testis, with different cell type-specificity from mouse Tcam1, and characterized its transcripts. At the mouse locus, a multifunctional dual promoter-enhancer (DPE) controls the expression of Tcam1 and Smarcd2 genes. The corresponding human sequence was found to potentially function as a DPE, although the molecular mechanism was different from mouse. Interestingly, the change in DPE activity occurred before pseudogenization of TCAM1P. These data suggest the presence of a DPE in the human genome for the first time, and provide an important model of evolutionary changes in the regulatory mechanism of a pseudogene. |
| Rights: | (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/58456 |
| Appears in Collections: | 理学院・理学研究院 (Graduate School of Science / Faculty of Science) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 木村 敦
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