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Nitric Oxide Produced During Ischemia Is Toxic but Crucial to Preconditioning-Induced Ischemic Tolerance of Neurons in Culture

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Title: Nitric Oxide Produced During Ischemia Is Toxic but Crucial to Preconditioning-Induced Ischemic Tolerance of Neurons in Culture
Authors: Kawahara, Koichi1 Browse this author →KAKEN DB
Yanoma, Junji Browse this author
Tanaka, Motoki Browse this author
Nakajima, Takayuki Browse this author
Kosugi, Tatsuro Browse this author
Authors(alt): 河原, 剛一1
Keywords: Ischemia
preconditioning
nitric oxide
neurotoxicity
cortical culture
Issue Date: Apr-2004
Publisher: Springer Netherlands
Journal Title: Neurochemical Research
Volume: 29
Issue: 4
Start Page: 797
End Page: 804
Publisher DOI: 10.1023/B:NERE.0000018853.30131.4d
Abstract: The present study investigated the roles of nitric oxide (NO) in preconditioning (PC)-induced neuronal ischemic tolerance in cortical cultures. Ischemia in vitro was simulated by subjecting cultures to both oxygen and glucose deprivation (OGD). A sublethal OGD (PC) significantly increased the survival rate of neurons when cultures were exposed to a lethal OGD 24 h later. Both the inhibition of nitric oxide synthase (NOS) and scavenging of NO during PC significantly attenuated the PC-induced neuronal tolerance. In addition, exposure to an NO donor emulated the PC. In contrast, the inhibition of NOS and the scavenging of NO during lethal OGD tended to increase the survival rate of neurons. This study suggested that NO produced during ischemia was fundamentally toxic, but critical to the development of PC-induced neuronal tolerance.
Rights: The original publication is available at www.springerlink.com. Former publisher: Kluwer Academic Publishers.
Type: article (author version)
URI: http://hdl.handle.net/2115/5933
Appears in Collections:情報科学院・情報科学研究院 (Graduate School of Information Science and Technology / Faculty of Information Science and Technology) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 河原 剛一

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