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Detailed Investigation on the Possibility of Nanoparticles of Various Metal Elements for Surface-Assisted Laser Desorption/Ionization Mass Spectrometry

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タイトル: Detailed Investigation on the Possibility of Nanoparticles of Various Metal Elements for Surface-Assisted Laser Desorption/Ionization Mass Spectrometry
著者: YONEZAWA, Tetsu 著作を一覧する
KAWASAKI, Hideya 著作を一覧する
TARUI, Akira 著作を一覧する
WATANABE, Takehiro 著作を一覧する
ARAKAWA, Ryuichi 著作を一覧する
SHIMADA, Toshihiro 著作を一覧する
MAFUNE, Fumitaka 著作を一覧する
発行日: 2009年 3月
出版者: Japan Society for Analytical Chemistry
誌名: Analytical Sciences
巻: 25
号: 3
開始ページ: 339
終了ページ: 346
抄録: In this paper, we describe systematic detailed considerations of the feasibility of using various metal nanoparticles for organic-matrix-free surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS). In order to avoid the influence of organic molecules on the nanoparticles, stabilizer-free bare nanoparticles of Ag, Au, Cu and Pt were prepared by laser ablation. Although all metal nanoparticles absorbed N2 laser light (337 nm) energy, the performance of desorption/ionization of a representative peptide, angiotensin I, strongly depended on the metal element. Citrate buffer was used as a proton source; it reduced the amount of alkali cation adducts present. Then, protonated molecules of analytes predominated in the mass spectra when Au and Pt nanoparticles were used. Pt nanoparticles showed the highest performance in SALDI-MS, owing to their smaller heat conductivity and higher melting temperature. The selective desorption of a cationic surfactant with longer alkyl chains and a peptide with methionine was also observed.
資料タイプ: article
URI: http://hdl.handle.net/2115/59715
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 米澤 徹

 

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