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Detailed Investigation on the Possibility of Nanoparticles of Various Metal Elements for Surface-Assisted Laser Desorption/Ionization Mass Spectrometry

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Title: Detailed Investigation on the Possibility of Nanoparticles of Various Metal Elements for Surface-Assisted Laser Desorption/Ionization Mass Spectrometry
Authors: YONEZAWA, Tetsu Browse this author →KAKEN DB
KAWASAKI, Hideya Browse this author
TARUI, Akira Browse this author
WATANABE, Takehiro Browse this author
ARAKAWA, Ryuichi Browse this author
SHIMADA, Toshihiro Browse this author
MAFUNE, Fumitaka Browse this author
Issue Date: Mar-2009
Publisher: Japan Society for Analytical Chemistry
Journal Title: Analytical Sciences
Volume: 25
Issue: 3
Start Page: 339
End Page: 346
Abstract: In this paper, we describe systematic detailed considerations of the feasibility of using various metal nanoparticles for organic-matrix-free surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS). In order to avoid the influence of organic molecules on the nanoparticles, stabilizer-free bare nanoparticles of Ag, Au, Cu and Pt were prepared by laser ablation. Although all metal nanoparticles absorbed N2 laser light (337 nm) energy, the performance of desorption/ionization of a representative peptide, angiotensin I, strongly depended on the metal element. Citrate buffer was used as a proton source; it reduced the amount of alkali cation adducts present. Then, protonated molecules of analytes predominated in the mass spectra when Au and Pt nanoparticles were used. Pt nanoparticles showed the highest performance in SALDI-MS, owing to their smaller heat conductivity and higher melting temperature. The selective desorption of a cationic surfactant with longer alkyl chains and a peptide with methionine was also observed.
Type: article
URI: http://hdl.handle.net/2115/59715
Appears in Collections:工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 米澤 徹

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