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Evaluation of the motion of lung tumors during stereotactic body radiation therapy (SBRT) with four-dimensional computed tomography (4DCT) using real-time tumor-tracking radiotherapy system (RTRT)

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PhysMed_32_305-supplD1.docxSupplementary material: Table S1. Characteristics of the 22 patients who were included in the analysis.19.57 kBMicrosoft Word XMLView/Open
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Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/61917

Title: Evaluation of the motion of lung tumors during stereotactic body radiation therapy (SBRT) with four-dimensional computed tomography (4DCT) using real-time tumor-tracking radiotherapy system (RTRT)
Authors: Harada, Keiichi Browse this author
Katoh, Norio Browse this author →KAKEN DB
Suzuki, Ryusuke Browse this author →KAKEN DB
Ito, Yoichi M. Browse this author →KAKEN DB
Shimizu, Shinichi Browse this author →KAKEN DB
Onimaru, Rikiya Browse this author →KAKEN DB
Inoue, Tetsuya Browse this author →KAKEN DB
Miyamoto, Naoki Browse this author →KAKEN DB
Shirato, Hiroki Browse this author →KAKEN DB
Keywords: Four-dimensional computed tomography
Stereotactic body radiation therapy
Real-time tumor-tracking radiotherapy
Organ motion
Issue Date: Feb-2016
Publisher: Elsevier
Journal Title: Physica medica : European journal of medical physics
Volume: 32
Issue: 2
Start Page: 305
End Page: 311
Publisher DOI: 10.1016/j.ejmp.2015.10.093
PMID: 26944253
Abstract: Purpose: We investigated the usefulness of four-dimensional computed tomography (4DCT) performed before stereotactic body radiation therapy (SBRT) in determining the internal margins for peripheral lung tumors. Methods and Materials: The amplitude of the movement of a fiducial marker near a lung tumor measured using the maximum intensity projection (MIP) method in 4DCT imaging was acquired before the SBRT (Amp(CT)) and compared with the mean amplitude of the marker movement during SBRT (Amp(mean)) and with the maximum amplitude of the marker movement during SBRT (Amp(max)) using a real-time tumortracking radiotherapy (RTRT) system with 22 patients. Results: There were no significant differences between the means of the Amp(mean) and the means of the Amp(CT) in all directions (LR, P = 0.45; CC, P = 0.80; AP, P = 0.65). The means of the Amp(max) were significantly larger than the means of the Amp(CT) in all directions (LR, P < 0.01; CC, P = 0.03; AP, P < 0.01). In the lower lobe, the mean difference of the Amp(CT) from the mean of the Amp(max) was 5.7 +/- 8.0 mm, 12.5 +/- 16.7 mm, and 6.8 +/- 8.5 mm in the LR, CC, and AP directions, respectively. Conclusions: Acquiring 4DCT MIP images before the SBRT treatment is useful to establish the mean amplitude for a patient during SBRT but it underestimates the maximum amplitude during actual SBRT. Caution must be paid to determine the margin with the 4DCT especially for tumors at the lower lobe where it is of the potentially greatest benefit.
Rights: http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article
URI: http://hdl.handle.net/2115/61917
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 加藤 徳雄

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