HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Graduate School of Medicine / Faculty of Medicine >
Peer-reviewed Journal Articles, etc >

The response time threshold for predicting favourable neurological outcomes in patients with bystander-witnessed out-of-hospital cardiac arrest

This item is licensed under: Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International

Files in This Item:
Resuscitation107_65-s1.docxSupplementary Table 196 kBMicrosoft Word XMLView/Open
Resuscitation107_65-s2.docxSupplementary Table 270.54 kBMicrosoft Word XMLView/Open
Resuscitation107_65.pdf529.97 kBPDFView/Open
Please use this identifier to cite or link to this item:http://hdl.handle.net/2115/67233

Title: The response time threshold for predicting favourable neurological outcomes in patients with bystander-witnessed out-of-hospital cardiac arrest
Authors: Ono, Yuichi Browse this author
Hayakawa, Mineji Browse this author →KAKEN DB
Iijima, Hiroaki Browse this author
Maekawa, Kunihiko Browse this author
Kodate, Akira Browse this author
Sadamoto, Yoshihiro Browse this author
Mizugaki, Asumi Browse this author
Murakami, Hiromoto Browse this author
Katabami, Kenichi Browse this author
Sawamura, Atsushi Browse this author →KAKEN DB
Gando, Satoshi Browse this author →KAKEN DB
Keywords: Out of hospital cardiac arrest
Neurological outcome
Response time
Issue Date: Oct-2016
Publisher: Elsevier
Journal Title: Resuscitation
Volume: 107
Start Page: 65
End Page: 70
Publisher DOI: 10.1016/j.resuscitation.2016.08.005
PMID: 27531022
Abstract: Objective: It is well established that the period of time between a call being made to emergency medical services (EMS) and the time at which EMS arrive at the scene (i.e., the response time) affects survival outcomes in patients who experienced out-of-hospital cardiac arrest (OHCA). However, the relationship between response time and favourable neurological outcomes remains unclear. We therefore aimed to determine a response time threshold in bystander-witnessed OHCA patients that is associated with positive neurological outcomes and to assess the relationship between response time and neurological outcomes in OHCA patients. Methods: This study was a retrospective, observational analysis of data from 204,277 episodes of bystander-witnessed OHCA between 2006 and 2012 in Japan. We used classification and regression trees (CARTs) and receiver operating characteristic (ROC) curve analysis to determine the threshold of response time associated with favourable neurological outcomes (Cerebral Performance Category 1 or 2) one month after cardiac arrest. Results: Both CARTs and ROC analyses indicated that a threshold of 6.5 min was associated with improved neurological outcomes in all bystander-witnessed OHCA events from cardiac origin. Furthermore, bystander cardiopulmonary resuscitation (CPR) prolonged the threshold of response time by 1 min (to 7.5 min). The adjusted odds ratios for favorable neurological outcomes in OHCA patients who received care within ≤ 6.5 min was 1.935 (95% confidential interval: 1.834-2.041, P<0.001). Conclusions: A response time ≤ 6.5 min was closely associated with favourable neurological outcomes in all bystander-witnessed OHCA patients. Bystander CPR prolonged the response time threshold by 1 min.
Rights: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
http://creativecommons.org/licenses/by-nc-nd/4.0/
Type: article (author version)
URI: http://hdl.handle.net/2115/67233
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 早川 峰司

Export metadata:

OAI-PMH ( junii2 , jpcoar )

MathJax is now OFF:


 

Feedback - Hokkaido University