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Fructose suppresses uric acid excretion to the intestinal lumen as a result of the induction of oxidative stress by NADPH oxidase activation

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タイトル: Fructose suppresses uric acid excretion to the intestinal lumen as a result of the induction of oxidative stress by NADPH oxidase activation
著者: Kaneko, Chihiro 著作を一覧する
Ogura, Jiro 著作を一覧する
Sasaki, Shunichi 著作を一覧する
Okamoto, Keisuke 著作を一覧する
Kobayashi, Masaki 著作を一覧する
Kuwayama, Kaori 著作を一覧する
Narumi, Katsuya 著作を一覧する
Iseki, Ken 著作を一覧する
キーワード: Hyperuricemia
Fructose
Uric acid excretion
Breast cancer resistance protein
Oxidative stress
NADPH oxidase
発行日: 2017年 3月
出版者: Elsevier
誌名: Biochimica et Biophysica Acta (BBA) General subjects
巻: 1861
号: 3
開始ページ: 559
終了ページ: 566
出版社 DOI: 10.1016/j.bbagen.2016.11.042
抄録: Background: A high intake of fructose increases the risk for hyperuricemia. It has been reported that long-term fructose consumption suppressed renal uric acid excretion and increased serum uric acid level. However, the effect of single administration of fructose on excretion of uric acid has not been clarified. Methods: We used male Wistar rats, which were orally administered fructose (5 g/kg). Those rats were used in each experiment at 12 h after administration. Results: Single administration of fructose suppressed the function of ileal uric acid excretion and had no effect on the function of renal uric acid excretion. Breast cancer resistance protein (BCRP) predominantly contributes to intestinal excretion of uric acid as an active homodimer. Single administration of fructose decreased BCRP homodimer level in the ileum. Moreover, diphenyleneiodonium (DPI), an inhibitor of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox), recovered the suppression of the function of ileal uric acid excretion and the Bcrp homodimer level in the ileum of rats that received single administration of fructose. Conclusions: Single administration of fructose decreases in BCRP homodimer level, resulting in the suppression the function of ileal uric acid excretion. The suppression of the function of ileal uric acid excretion by single administration of fructose is caused by the activation of Nox. The results of our study provide a new insight into the mechanism of fructose-induced hyperuricemia. (C) 2016 Elsevier B.V. All rights reserved.
Rights: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/68654
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 小林 正紀

 

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