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Effects of prenatal exposure to perfluoroalkyl acids on prevalence of allergic diseases among 4-year-old children

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Title: Effects of prenatal exposure to perfluoroalkyl acids on prevalence of allergic diseases among 4-year-old children
Authors: Goudarzi, Houman Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Okada, Emiko Browse this author →KAKEN DB
Kashino, Ikuko Browse this author
Kobayashi, Sumitaka Browse this author →KAKEN DB
Chen, Chi-Jen Browse this author
Ito, Sachiko Browse this author
Araki, Atsuko Browse this author →KAKEN DB
Matsuura, Hideyuki Browse this author →KAKEN DB
Ito, Yoichi M. Browse this author →KAKEN DB
Kishi, Reiko Browse this author →KAKEN DB
Keywords: PFAAs
Birth cohorts
Children's health
Prenatal exposure
Issue Date: Sep-2016
Publisher: Elsevier
Journal Title: Environment international
Volume: 94
Start Page: 124
End Page: 132
Publisher DOI: 10.1016/j.envint.2016.05.020
PMID: 27236407
Abstract: Perfluoroalkyl acids (PFAAs) are ubiquitous chemicals extremely resistant and widespread throughout the environment, frequently being detected in human blood samples. Animal studies have revealed that exposure to PFAAs results in immunotoxicity. However, the association between PFAAs, especially long-chain PFAAs, and allergies in humans is not well established. We examined whether prenatal exposure to PFAAs is associated with allergic diseases among 4-year-old children in a large-scale prospective birth cohort in Hokkaido, Japan. In total, 1558 mother-child pairs were included in this study and prenatal levels of eleven PFAAs were measured in maternal plasma samples obtained between 28 and 32 weeks of pregnancy by using ultra-performance liquid chromatography-tandem mass spectrometry. Participant demographic and characteristic information were obtained from self-administered pre- and postnatal questionnaires and medical birth records. Infant allergies were assessed using the Japanese version of the International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three questionnaire, which was administered 4 years post-delivery. Symptoms included eczema, wheezing and rhinoconjunctivitis with a prevalence of 19.0%, 18.7%, and 5.4%, respectively. Associations of PFAA quartiles with allergic outcomes were examined using logistic models. Adjusted odds ratios (ORs) in the 4th quartile vs. 1st quartile (Q4 vs. Q1) for total allergic diseases (including at least one allergic outcome) significantly decreased for perfluorododecanoic acid (PFDoDa) (Q4 vs. Q1 OR: 0.621; 95% confidence interval (CI): 0.454, 0.847) andperfluorotridecanoic acid (PFTrDA) (Q4 vs. Q1 OR: 0.712; 95% CI: 0.524, 0.966) in all children. We obtained similar results when examining the association between PFAAs and eczema. The adjusted OR (Q4 vs. Q1) for wheezing in relation to higher maternal PFHxS levels was 0.728 (95% CI: 0.497, 1.06) in all children. In conclusion, prenatal exposure to long-chain PFAAs, such as PFDoDa and PFTrDA may have an immunosuppressive effect on allergic diseases in 4-year-old children.
Rights: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 岸 玲子

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