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Control of PD-L1 expression by miR-140/142/340/383 and oncogenic activation of the OCT4–miR-18a pathway in cervical cancer

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Title: Control of PD-L1 expression by miR-140/142/340/383 and oncogenic activation of the OCT4–miR-18a pathway in cervical cancer
Authors: Dong, Peixin Browse this author →KAKEN DB
Xiong, Ying Browse this author
Yu, Jiehai Browse this author
Chen, Lin Browse this author
Tao, Tang Browse this author
Yi, Song Browse this author
Hanley, Sharon J.B. Browse this author →KAKEN DB
Yue, Junming Browse this author
Watari, Hidemichi Browse this author →KAKEN DB
Sakuragi, Noriaki Browse this author →KAKEN DB
Issue Date: 27-Sep-2018
Publisher: Nature Publishing Group
Journal Title: Oncogene
Volume: 37
Issue: 39
Start Page: 5257
End Page: 5268
Publisher DOI: 10.1038/s41388-018-0347-4
Abstract: PD-L1, a key inhibitory immune receptor, has crucial functions in cancer immune evasion, but whether PD-L1 promotes the malignant properties of cervical cancer (CC) cells and the mechanism by which PD-L1 is regulated in CC remains unclear. We report that PD-L1 is overexpressed in CC, and shRNA-mediated PD-L1 depletion suppresses the proliferation, invasion, and tumorigenesis of CC cells. Loss of miR-140/142/340/383 contributes to PD-L1 upregulation. miR-18a enhances PD-L1 levels by targeting PTEN, WNK2 (ERK1/2 pathway inhibitor), and SOX6 (Wnt/β-catenin pathway inhibitor and p53 pathway activator) to activate the PI3K/AKT, MEK/ERK, and Wnt/β-catenin pathways and inhibit the p53 pathway, and miR-18a also directly suppresses the expression of the tumor suppressors BTG3 and RBSP3 (CTDSPL). miR-18a overexpression in CC cells is triggered by OCT4 overexpression. Our data implicate PD-L1 as a novel oncoprotein and indicate that miR-140/142/340/383 and miR-18a are key upstream regulators of PD-L1 and potential targets for CC treatment.
Type: article
Appears in Collections:医学院・医学研究院 (Graduate School of Medicine / Faculty of Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 董 培新

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