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Hokkaido University Collection of Scholarly and Academic Papers >
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Uptake of Transition Metal Ions Using Liposomes Containing Dicetylphosphate as a Ligand
| Title: | Uptake of Transition Metal Ions Using Liposomes Containing Dicetylphosphate as a Ligand |
| Authors: | KAMIDATE, Tamio Browse this author | | HASHIMOTO, Yasunori Browse this author | | TANI, Hirofumi Browse this author →KAKEN DB | | ISHIDA, Akihiko Browse this author |
| Keywords: | phosphatidylcholine (PC) |
| Issue Date: | Mar-2002 |
| Publisher: | 日本分析化学会 |
| Journal Title: | Analytical Sciences |
| Volume: | 18 |
| Issue: | 3 |
| Start Page: | 273 |
| End Page: | 276 |
| Publisher DOI: | 10.2116/analsci.18.273 |
| Abstract: | The uptake of Cu2+ was investigated using various types of liposomes composed of phosphatidylcholine (PC), cholesterol (Chol) and dicethylphosphate (DCP). DCP played a role as a ligand for Cu2+. Multilamellar vesicles (MLVs) were more effective for the uptake of Cu2+ compared to unilamellar vesicles prepared by the extrusion technique. The uptake efficiency of MLVs for Cu2+ was dependent on the molar ratio of DCP in MLVs. The uptake percent of Cu2+ was 92% using MLVs having a PC:DCP:Chol molar ratio of 4:3:3; 95% of the total vesicle Cu2+ was bound to DCP of the outer membrane surface of the MLVs, and the remaining 5% of the total Cu2+ was distributed into the interior side of the MLVs. MLVs having a PC:DCP:Chol molar ratio of 4:3:3 were also effective as separation media for Mn2+, Co2+, Ni2+ and Zn2+. The uptake efficiency of the MLVs for the transition-metal ions increased in the order Co2+< Zn2+ < Ni2+ < Mn2+ < Cu2+. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/71712 |
| Appears in Collections: | 工学院・工学研究院 (Graduate School of Engineering / Faculty of Engineering) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 谷 博文
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