| Title: | Novel Ultrasonographic Scoring System of Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation |
| Authors: | Nishida, Mutsumi Browse this author →KAKEN DB |
| Kahata, Kaoru Browse this author |
| Hayase, Eiko Browse this author |
| Shigematsu, Akio Browse this author |
| Sato, Megumi Browse this author |
| Kudo, Yusuke Browse this author |
| Omotehara, Satomi Browse this author |
| Iwai, Takahito Browse this author |
| Sugita, Junichi Browse this author |
| Shibuya, Hitoshi Browse this author |
| Shimizu, Chikara Browse this author →KAKEN DB |
| Teshima, Takanori Browse this author →KAKEN DB |
| Keywords: | Sinusoidal obstruction syndrome |
| Hepatic veno-occlusive disease |
| Ultrasonography |
| Color Doppler |
| Hematopoietic stem cell transplantation |
| Issue Date: | Sep-2018 |
| Publisher: | Elsevier |
| Journal Title: | Biology of blood and marrow transplantation |
| Volume: | 24 |
| Issue: | 9 |
| Start Page: | 1896 |
| End Page: | 1900 |
| Publisher DOI: | 10.1016/j.bbmt.2018.05.025 |
| PMID: | 29803752 |
| Abstract: | Sinusoidal obstruction syndrome (SOS)/hepatic veno-occlusive disease (VOD) is a well-documented complication after hematopoietic stem cell transplantation (HSCT). Transabdominal ultrasonography (US) enables the visualization of blood flow abnormalities and is therefore useful for the diagnosis of SOS/VOD. We herein prospectively evaluated accuracy of a novel US diagnostic scoring system of SOS/VOD based on US findings. We carried out US in 106 patients on day 14 and when SOS/VOD was suspected after allogeneic HSCT. Among 106 patients, 10 patients (9.4%) were diagnosed as SOS/VOD by Baltimore or Seattle criteria. According to uni-variate analysis of 17 US findings (US-17 screening), we established a novel scoring system (HokUS-10) consisting of 10 parameters, such as gallbladder wall thickening, ascites, and blood flow signal in the paraumbilical vein. The sensitivity and specificity were 100% and 95.8%, respectively. Diagnostic performance of the HokUS-10 was significantly better than US-17 screening. In 4 of 10 patients US detection of SOS/VOD preceded to clinical diagnosis. The HokUS-10 scoring system is useful in the diagnosis of SOS/VOD; however, our results should be validated in other cohorts. |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article |
| URI: | http://hdl.handle.net/2115/72046 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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