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Novel Ultrasonographic Scoring System of Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation

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Title: Novel Ultrasonographic Scoring System of Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation
Authors: Nishida, Mutsumi Browse this author →KAKEN DB
Kahata, Kaoru Browse this author
Hayase, Eiko Browse this author
Shigematsu, Akio Browse this author
Sato, Megumi Browse this author
Kudo, Yusuke Browse this author
Omotehara, Satomi Browse this author
Iwai, Takahito Browse this author
Sugita, Junichi Browse this author
Shibuya, Hitoshi Browse this author
Shimizu, Chikara Browse this author →KAKEN DB
Teshima, Takanori Browse this author →KAKEN DB
Keywords: Sinusoidal obstruction syndrome
Hepatic veno-occlusive disease
Color Doppler
Hematopoietic stem cell transplantation
Issue Date: Sep-2018
Publisher: Elsevier
Journal Title: Biology of blood and marrow transplantation
Volume: 24
Issue: 9
Start Page: 1896
End Page: 1900
Publisher DOI: 10.1016/j.bbmt.2018.05.025
PMID: 29803752
Abstract: Sinusoidal obstruction syndrome (SOS)/hepatic veno-occlusive disease (VOD) is a well-documented complication after hematopoietic stem cell transplantation (HSCT). Transabdominal ultrasonography (US) enables the visualization of blood flow abnormalities and is therefore useful for the diagnosis of SOS/VOD. We herein prospectively evaluated accuracy of a novel US diagnostic scoring system of SOS/VOD based on US findings. We carried out US in 106 patients on day 14 and when SOS/VOD was suspected after allogeneic HSCT. Among 106 patients, 10 patients (9.4%) were diagnosed as SOS/VOD by Baltimore or Seattle criteria. According to uni-variate analysis of 17 US findings (US-17 screening), we established a novel scoring system (HokUS-10) consisting of 10 parameters, such as gallbladder wall thickening, ascites, and blood flow signal in the paraumbilical vein. The sensitivity and specificity were 100% and 95.8%, respectively. Diagnostic performance of the HokUS-10 was significantly better than US-17 screening. In 4 of 10 patients US detection of SOS/VOD preceded to clinical diagnosis. The HokUS-10 scoring system is useful in the diagnosis of SOS/VOD; however, our results should be validated in other cohorts.
Type: article
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 西田 睦

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