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Synthesis and biological evaluation of a MraY selective analogue of tunicamycins
| Title: | Synthesis and biological evaluation of a MraY selective analogue of tunicamycins |
| Authors: | Yamamoto, Kazuki Browse this author | | Sato, Toyotaka Browse this author | | Hikiji, Yuta Browse this author | | Katsuyama, Akira Browse this author | | Matsumaru, Takanori Browse this author | | Yakushiji, Fumika Browse this author →KAKEN DB | | Yokota, Shin-Ichi Browse this author | | Ichikawa, Satoshi Browse this author →KAKEN DB |
| Keywords: | antibacterial | | nucleoside natural products | | organic chemistry |
| Issue Date: | 30-Sep-2019 |
| Publisher: | Taylor & Francis |
| Journal Title: | Nucleosides, nucleotides & nucleic acids |
| Volume: | 39 |
| Issue: | 13 |
| Start Page: | 349 |
| End Page: | 364 |
| Publisher DOI: | 10.1080/15257770.2019.1649696 |
| Abstract: | Tunicamycins, which are nucleoside natural products, inhibit both bacterial phospho-N-acetylmuraminic acid (MurNAc)-pentapeptide translocase (MraY) and human UDP-N-acetylglucosamine (GlcNAc): polyprenol phosphate translocase (GPT). The improved synthesis and detailed biological evaluation of an MraY-selective inhibitor, 2, where the GlcNAc moiety was modified to a MurNAc amide, has been described. |
| Rights: | This is an Accepted Manuscript of an article published by Taylor & Francis in Nucleosides, nucleotides & nucleic acids on 30 Sep 2019, available online: http://www.tandfonline.com/doi/full/10.1080/15257770.2019.1649696. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/79340 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 市川 聡
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