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Synthesis and biological evaluation of a MraY selective analogue of tunicamycins

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Title: Synthesis and biological evaluation of a MraY selective analogue of tunicamycins
Authors: Yamamoto, Kazuki Browse this author
Sato, Toyotaka Browse this author
Hikiji, Yuta Browse this author
Katsuyama, Akira Browse this author
Matsumaru, Takanori Browse this author
Yakushiji, Fumika Browse this author →KAKEN DB
Yokota, Shin-Ichi Browse this author
Ichikawa, Satoshi Browse this author →KAKEN DB
Keywords: antibacterial
nucleoside natural products
organic chemistry
Issue Date: 30-Sep-2019
Publisher: Taylor & Francis
Journal Title: Nucleosides, nucleotides & nucleic acids
Volume: 39
Issue: 13
Start Page: 349
End Page: 364
Publisher DOI: 10.1080/15257770.2019.1649696
Abstract: Tunicamycins, which are nucleoside natural products, inhibit both bacterial phospho-N-acetylmuraminic acid (MurNAc)-pentapeptide translocase (MraY) and human UDP-N-acetylglucosamine (GlcNAc): polyprenol phosphate translocase (GPT). The improved synthesis and detailed biological evaluation of an MraY-selective inhibitor, 2, where the GlcNAc moiety was modified to a MurNAc amide, has been described.
Rights: This is an Accepted Manuscript of an article published by Taylor & Francis in Nucleosides, nucleotides & nucleic acids on 30 Sep 2019, available online:
Type: article (author version)
Appears in Collections:薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 市川 聡

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