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Association of maternal serum concentration of hydroxylated polychlorinated biphenyls with maternal and neonatal thyroid hormones : The Hokkaido birth cohort study

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Title: Association of maternal serum concentration of hydroxylated polychlorinated biphenyls with maternal and neonatal thyroid hormones : The Hokkaido birth cohort study
Other Titles: Hydroxylated-PCB exposure and thyroid hormones
Authors: Itoh, Sachiko Browse this author →KAKEN DB
Baba, Toshiaki Browse this author
Yuasa, Motoyuki Browse this author →KAKEN DB
Miyashita, Chihiro Browse this author →KAKEN DB
Kobayashi, Sumitaka Browse this author →KAKEN DB
Araki, Atsuko Browse this author →KAKEN DB
Sasaki, Seiko Browse this author →KAKEN DB
Kajiwara, Jumboku Browse this author
Hori, Tsuguhide Browse this author
Todaka, Takashi Browse this author
Fujikura, Kaori Browse this author
Nakajima, Sonomi Browse this author
Kato, Shizue Browse this author
Kishi, Reiko Browse this author →KAKEN DB
Keywords: Prenatal exposure
Hydroxylated polychlorinated biphenyls
Prospective cohort study
Thyroid hormone
Structural equation modeling
Issue Date: Nov-2018
Publisher: Elsevier
Journal Title: Environmental Research
Volume: 167
Start Page: 583
End Page: 590
Publisher DOI: 10.1016/j.envres.2018.08.027
Abstract: Background: Evidence on the toxicity of hydroxylated metabolites of polychlorinated biphenyls (OH-PCBs) for thyroid hormones (TH) is limited, and the underlying mechanism remains unknown. Objectives: We aimed to investigate the effects of environmental prenatal exposure to OH-PCBs and maternal and neonatal TH levels, taking the maternal-fetal TH transfer into account. Methods: In this prospective birth cohort (the "Hokkaido study") we included 222 mother-neonate pairs. We measured five OH-PCB isomers in maternal serum samples either during pregnancy or within 5 days of delivery. Thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels were obtained from maternal blood samples at an early gestational stage (median; 11.1 weeks) and from heel prick samples of neonates between 4 and 7 days after birth. Multiple linear regression analysis and structural equation modeling (SEM) were performed to investigate the associations between maternal OH-PCB and maternal and neonatal TH levels. Results: Median concentration of ΣOH-PCBs was 25.37 pg/g wet weight. The predominant isomer was 4-OH-CB187, followed by 4-OH-CB146+3-OH-CB153. In the fully adjusted linear regression analysis, maternal ΣOH-PCBs was positively associated with maternal FT4, and 4-OH-CB187 was positively associated with both maternal and neonatal FT4 levels. Maternal OH-PCBs showed no significant association with TSH among mothers and neonates. Path analysis indicated the indirect pathway from 4-OH-CB187 exposure to increased neonatal FT4, via maternal THs and neonatal TSH. Conclusions: These findings suggest that maternal exposure to OH-PCBs during pregnancy may increase both maternal and neonatal FT4 levels. Neonatal FT4 is presumed to be increased by prenatal 4-OH-CB187 indirectly, and this process may be mediated by maternal THs and neonatal TSH.
Rights: © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 伊藤 佐智子

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