Title: | Association of maternal serum concentration of hydroxylated polychlorinated biphenyls with maternal and neonatal thyroid hormones : The Hokkaido birth cohort study |
Other Titles: | Hydroxylated-PCB exposure and thyroid hormones |
Authors: | Itoh, Sachiko Browse this author →KAKEN DB |
Baba, Toshiaki Browse this author |
Yuasa, Motoyuki Browse this author →KAKEN DB |
Miyashita, Chihiro Browse this author →KAKEN DB |
Kobayashi, Sumitaka Browse this author →KAKEN DB |
Araki, Atsuko Browse this author →KAKEN DB |
Sasaki, Seiko Browse this author →KAKEN DB |
Kajiwara, Jumboku Browse this author |
Hori, Tsuguhide Browse this author |
Todaka, Takashi Browse this author |
Fujikura, Kaori Browse this author |
Nakajima, Sonomi Browse this author |
Kato, Shizue Browse this author |
Kishi, Reiko Browse this author →KAKEN DB |
Keywords: | Prenatal exposure |
Hydroxylated polychlorinated biphenyls |
Prospective cohort study |
Thyroid hormone |
Structural equation modeling |
Issue Date: | Nov-2018 |
Publisher: | Elsevier |
Journal Title: | Environmental Research |
Volume: | 167 |
Start Page: | 583 |
End Page: | 590 |
Publisher DOI: | 10.1016/j.envres.2018.08.027 |
Abstract: | Background: Evidence on the toxicity of hydroxylated metabolites of polychlorinated biphenyls (OH-PCBs) for thyroid hormones (TH) is limited, and the underlying mechanism remains unknown. Objectives: We aimed to investigate the effects of environmental prenatal exposure to OH-PCBs and maternal and neonatal TH levels, taking the maternal-fetal TH transfer into account. Methods: In this prospective birth cohort (the "Hokkaido study") we included 222 mother-neonate pairs. We measured five OH-PCB isomers in maternal serum samples either during pregnancy or within 5 days of delivery. Thyroid stimulating hormone (TSH) and free thyroxine (FT4) levels were obtained from maternal blood samples at an early gestational stage (median; 11.1 weeks) and from heel prick samples of neonates between 4 and 7 days after birth. Multiple linear regression analysis and structural equation modeling (SEM) were performed to investigate the associations between maternal OH-PCB and maternal and neonatal TH levels. Results: Median concentration of ΣOH-PCBs was 25.37 pg/g wet weight. The predominant isomer was 4-OH-CB187, followed by 4-OH-CB146+3-OH-CB153. In the fully adjusted linear regression analysis, maternal ΣOH-PCBs was positively associated with maternal FT4, and 4-OH-CB187 was positively associated with both maternal and neonatal FT4 levels. Maternal OH-PCBs showed no significant association with TSH among mothers and neonates. Path analysis indicated the indirect pathway from 4-OH-CB187 exposure to increased neonatal FT4, via maternal THs and neonatal TSH. Conclusions: These findings suggest that maternal exposure to OH-PCBs during pregnancy may increase both maternal and neonatal FT4 levels. Neonatal FT4 is presumed to be increased by prenatal 4-OH-CB187 indirectly, and this process may be mediated by maternal THs and neonatal TSH. |
Rights: | © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ |
http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Type: | article (author version) |
URI: | http://hdl.handle.net/2115/79664 |
Appears in Collections: | 環境健康科学研究教育センター (Center for Environmental and Health Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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