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Insights into phosphatase-activated chemical defense in a marine sponge holobiont
| Title: | Insights into phosphatase-activated chemical defense in a marine sponge holobiont |
| Authors: | Jomori, Takahiro Browse this author | | Matsuda, Kenichi Browse this author →KAKEN DB | | Egami, Yoko Browse this author →KAKEN DB | | Abe, Ikuro Browse this author →KAKEN DB | | Takai, Akira Browse this author →KAKEN DB | | Wakimoto, Toshiyuki Browse this author →KAKEN DB |
| Issue Date: | 6-Oct-2021 |
| Publisher: | Royal Society of Chemistry |
| Journal Title: | RSC Chemical Biology |
| Volume: | 2 |
| Issue: | 6 |
| Start Page: | 1600 |
| End Page: | 1607 |
| Publisher DOI: | 10.1039/d1cb00163a |
| Abstract: | Marine sponges often contain potent cytotoxic compounds, which in turn evokes the principle question of how marine sponges avoid self-toxicity. In a marine sponge Discodermia calyx, the highly toxic calyculin A is detoxified by the phosphorylation, which is catalyzed by the phosphotransferase CalQ of a producer symbiont, "Candidatus Entotheonella" sp. Here we show the activating mechanism to dephosphorylate the stored phosphocalyculin A protoxin. The phosphatase specific to phosphocalyculin A is CalL, which is also encoded in the calyculin biosynthetic gene cluster. CalL represents a new clade and unprecedently coordinates the heteronuclear metals Cu and Zn. CalL is localized in the periplasmic space of the sponge symbiont, where it is ready for the on-demand production of calyculin A in response to sponge tissue disruption. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/83835 |
| Appears in Collections: | 国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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