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Insights into phosphatase-activated chemical defense in a marine sponge holobiont

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Title: Insights into phosphatase-activated chemical defense in a marine sponge holobiont
Authors: Jomori, Takahiro Browse this author
Matsuda, Kenichi Browse this author →KAKEN DB
Egami, Yoko Browse this author →KAKEN DB
Abe, Ikuro Browse this author →KAKEN DB
Takai, Akira Browse this author →KAKEN DB
Wakimoto, Toshiyuki Browse this author →KAKEN DB
Issue Date: 6-Oct-2021
Publisher: Royal Society of Chemistry
Journal Title: RSC Chemical Biology
Volume: 2
Issue: 6
Start Page: 1600
End Page: 1607
Publisher DOI: 10.1039/d1cb00163a
Abstract: Marine sponges often contain potent cytotoxic compounds, which in turn evokes the principle question of how marine sponges avoid self-toxicity. In a marine sponge Discodermia calyx, the highly toxic calyculin A is detoxified by the phosphorylation, which is catalyzed by the phosphotransferase CalQ of a producer symbiont, "Candidatus Entotheonella" sp. Here we show the activating mechanism to dephosphorylate the stored phosphocalyculin A protoxin. The phosphatase specific to phosphocalyculin A is CalL, which is also encoded in the calyculin biosynthetic gene cluster. CalL represents a new clade and unprecedently coordinates the heteronuclear metals Cu and Zn. CalL is localized in the periplasmic space of the sponge symbiont, where it is ready for the on-demand production of calyculin A in response to sponge tissue disruption.
Type: article
Appears in Collections:国際連携研究教育局 : GI-CoRE (Global Institution for Collaborative Research and Education : GI-CoRE) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

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