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Enhancement of self-sustained muscle activity through external dead space ventilation appears to be associated with hypercapnia

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Title: Enhancement of self-sustained muscle activity through external dead space ventilation appears to be associated with hypercapnia
Authors: Hatano, Kei Browse this author
Matsuura, Ryouta Browse this author →KAKEN DB
Ohtsuka, Yoshinori Browse this author →KAKEN DB
Yunoki, Takahiro Browse this author →KAKEN DB
Keywords: Hypercapnia
Central chemoreceptors
Self-sustained muscle activity
Plateau potentials
Issue Date: Jan-2022
Publisher: Elsevier
Journal Title: Respiratory physiology & neurobiology
Volume: 295
Start Page: 103777
Publisher DOI: 10.1016/j.resp.2021.103777
PMID: 34425262
Abstract: We reported that external dead space ventilation (EDSV) enhanced self-sustained muscle activity (SSMA) of the human soleus muscle, which is an indirect observation of plateau potentials. However, the main factor for EDSV to enhance SSMA remains unclear. The purpose of the present study was to examine the effects of EDSV-induced hypercapnia, hypoxia, and hyperventilation on SSMA. In Experiment 1 (n = 11; normal breathing [NB], EDSV, hypoxia, and voluntary hyperventilation conditions) and Experiment 2 (n = 9; NB and normoxic hypercapnia [NH] conditions), SSMA was evoked by electrical train stimulations of the right tibial nerve and measured using surface electromyography under each respiratory condition. In Experiment 1, SSMA was significantly higher than that in the NB condition only in the EDSV condition (P < 0.05). In Experiment 2, SSMA was higher in the NH condition than in the NB condition (P < 0.05). These results suggest that the EDSV-enhanced SSMA is due to hypercapnia, not hypoxia or increased ventilation.
Rights: © 2021, Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:教育学院・教育学研究院 (Graduate School of Education / Faculty of Education) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 柚木 孝敬

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