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Regioselective Deaminative Allylation of Aliphatic Amines via Dual Cobalt and Organophotoredox Catalysis
| Title: | Regioselective Deaminative Allylation of Aliphatic Amines via Dual Cobalt and Organophotoredox Catalysis |
| Authors: | Sekino, Tomoyuki Browse this author | | Sato, Shunta Browse this author | | Yoshino, Tatsuhiko Browse this author →KAKEN DB | | Kojima, Masahiro Browse this author →KAKEN DB | | Matsunaga, Shigeki Browse this author →KAKEN DB |
| Issue Date: | 9-Mar-2022 |
| Publisher: | American Chemical Society |
| Journal Title: | Organic letters |
| Volume: | 24 |
| Issue: | 11 |
| Start Page: | 2120 |
| End Page: | 2124 |
| Publisher DOI: | 10.1021/acs.orglett.2c00319 |
| Abstract: | Despite the rapid progress in C-C bond-forming reactions using Katritzky salts, their deaminative allylation remains a challenge. Inspired by the metallaphotoredox-catalyzed allylic substitution regime, here, we report the deaminative allylation of Katritzky salts via cobalt/organophotoredox dual catalysis. This cross-electrophile coupling enables regioselective allylation using a variety of allylic esters, overcoming the substrate limitations of reported protocols. Mechanistic studies indicate the involvement of a pi-allyl cobalt complex as a radicalophile that mediates C-C bond formation. |
| Rights: | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/articlesonrequest/AOR-H4JCPXJAFRYRTCC68BPH. |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/88762 |
| Appears in Collections: | 薬学研究院 (Faculty of Pharmaceutical Sciences) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 小島 正寛
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