HUSCAP logo Hokkaido Univ. logo

Hokkaido University Collection of Scholarly and Academic Papers >
Hokkaido University Hospital >
Peer-reviewed Journal Articles, etc >

Hepatic drug metabolism in older people with body composition changes

Files in This Item:
Figure_S1_SuppInfo.docxFigure S126.78 kBMicrosoft Word XMLView/Open
Figure_S2_SuppInfo.docxFigure S239.88 kBMicrosoft Word XMLView/Open
GGI 22(5) 449-454.pdfMain text624.9 kBPDFView/Open
Graphical Abstract Text.docx27.13 kBMicrosoft Word XMLView/Open
Methods_SuppInfo.docxData S116.27 kBMicrosoft Word XMLView/Open
Table_S1_SuppInfo.docxTable S146.07 kBMicrosoft Word XMLView/Open
Table_S2_SuppInfo.docxTable S218.84 kBMicrosoft Word XMLView/Open
Please use this identifier to cite or link to this item:

Title: Hepatic drug metabolism in older people with body composition changes
Authors: Kaburaki, Soyoko Browse this author
Yoshimura, Eri Browse this author
Miyamoto, Yasushi Browse this author
Imai, Shungo Browse this author
Kashiwagi, Hitoshi Browse this author
Ueno, Hidefumi Browse this author
Sugawara, Mitsuru Browse this author
Takekuma, Yoh Browse this author →KAKEN DB
Keywords: handgrip strength
hepatic drug metabolism
older patients
skeletal muscle mass
Issue Date: 1-May-2022
Publisher: John Wiley & Sons
Journal Title: Geriatrics & gerontology international
Volume: 22
Issue: 5
Start Page: 449
End Page: 454
Publisher DOI: 10.1111/ggi.14380
Abstract: Aim Dosage adjustment is essential in older individuals because they are prone to experience a decline in liver function and changes in body composition. However, quantitative tests or equations for evaluating the activity of hepatic drug metabolism have not yet been clearly established. We examined hepatic drug metabolism activities in older individuals, focusing on changes in body composition parameters. Methods Lansoprazole and nifedipine, substrates of the metabolic enzymes cytochrome P450 (CYP) 2C19 and 3A4, respectively, were selected to study hepatic drug metabolism. Residual samples from blood test for older patients were evaluated to determine drug metabolism. The body composition of relevant patients was determined by analyzing characteristic parameters of skeletal muscle mass index (SMI), handgrip strength (HGS) and hepatic steatosis index (HSI). The differences in hepatic drug metabolism were studied statistically among categories in terms of the cut-off value of these parameters. Results Older male patients receiving lansoprazole and nifedipine in the low SMI (<7.0 kg/m(2)) category showed an 85-90% reduction in respective CYP2C19 and CYP3A4 metabolic activities compared with the normal SMI category. For the female patients, CYP2C19 and CYP3A4 metabolic activities showed no significant correlation with SMI and HGS. Fatty liver disease (HSI >= 36) was found to reduce CYP2C19 metabolic activity particularly in older female patients. Conclusions Low CYP2C19 metabolic activity was statistically correlated with low SMI in male patients and high HSI in female patients, whereas low CYP3A4 metabolic activity was statistically correlated with low HGS in male patients.
Rights: This is the peer reviewed version of the following article: Kaburaki, S, Yoshimura, E, Miyamoto, Y, et al. Hepatic drug metabolism in older people with body composition changes. Geriatr. Gerontol. Int. 2022; 22: 449– 454. which has been published in final form at 10.1111/ggi.14380. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
Type: article (author version)
Appears in Collections:北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 武隈 洋

Export metadata:

OAI-PMH ( junii2 , jpcoar_1.0 )

MathJax is now OFF:


 - Hokkaido University