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Assessment of LeadCare (R) II analysis for testing of a wide range of blood lead levels in comparison with ICP-MS analysis

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Title: Assessment of LeadCare (R) II analysis for testing of a wide range of blood lead levels in comparison with ICP-MS analysis
Authors: Nakata, Hokuto Browse this author →KAKEN DB
Nakayama, Shouta M. M. Browse this author →KAKEN DB
Yabe, John Browse this author
Muzandu, Kaampwe Browse this author
Toyomaki, Haruya Browse this author
Yohannes, Yared Beyene Browse this author
Kataba, Andrew Browse this author
Zyambo, Golden Browse this author
Ikenaka, Yoshinori Browse this author →KAKEN DB
Choongo, Kennedy Browse this author
Ishizuka, Mayumi Browse this author →KAKEN DB
Keywords: LeadCare
Bland-altman analysis
Passing-bablok regression
Deming regression
Issue Date: May-2021
Publisher: Elsevier
Journal Title: Chemosphere
Volume: 271
Start Page: 129832
Publisher DOI: 10.1016/j.chemosphere.2021.129832
Abstract: The LeadCare (R) testing system, which utilizes anodic stripping voltammetry (ASV) methodology, has been widely used worldwide for cost-effective blood lead level (BLL) screening. However, some concerns have recently been issued regarding inaccurate results obtained using LeadCare (R). Hence, we aimed to evaluate the accuracy of BLL measured by LeadCare (R) II (BLLLC) by comparison with ICP-MS (BLLIM) by the Passing-Bablok regression, Deming regression, and Bland-Altman analyses by using 994 venous blood samples. BLLLC ranged from 3.3 to 162.3 mu g/dL, while BLLIM ranged from 0.8 to 154.8 mu g/dL. Although BLLLC and BLLIM exhibited a strong and positive correlation, BLLLC values were generally greater than BLLIM values, indicative of the overestimation of the LeadCare (R) analysis. A large positive bias of 19.15 +/- 8.26 mg/dL and 29.25 +/- 14.04 mu g/dL for BLLLC compared with BLLIM were recorded in the BLLLC range of 45.0-64.9 mu g/dL and for >= 65.0 mu g/dL, respectively. In contrast, a bias of <= 0.3 mu g/dL was observed at a BLLLC of less than 10.0 mu g/dL. Blood copper, cadmium, and iron levels did not exhibit an effect on the bias of BLLLC, indicative of the minimal potential interferences of the metals; these interferences are a cause for concern with the ASV method. In conclusion, LeadCare (R) analysis is thought to be a good tool for screening purposes at a lower BLL around the reference level of 5 mg/dL in the initial stage; however, conversion or retesting using a laboratory analyzer is recommended at a higher BLL for appropriate clinical evaluation and research. (C) 2021 Elsevier Ltd. All rights reserved.
Rights: © <2021>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Type: article (author version)
Appears in Collections:獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

Submitter: 石塚 真由美

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