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A fixed single meal in the subjective day prevents free-running of the human sleep-wake cycle but not of the circadian pacemaker under temporal isolation
| Title: | A fixed single meal in the subjective day prevents free-running of the human sleep-wake cycle but not of the circadian pacemaker under temporal isolation |
| Authors: | Yamanaka, Yujiro Browse this author →KAKEN DB | | Hashimoto, Satoko Browse this author | | Honma, Aya Browse this author | | Honma, Sato Browse this author →KAKEN DB | | Honma, Ken-ichi Browse this author →KAKEN DB |
| Keywords: | circadian pacemaker | | free-running | | nonphotic entrainment | | single meal | | sleep-wake cycle |
| Issue Date: | Jul-2022 |
| Publisher: | American Physiological Society |
| Journal Title: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology |
| Volume: | 323 |
| Issue: | 1 |
| Start Page: | R16 |
| End Page: | R27 |
| Publisher DOI: | 10.1152/ajpregu.00262.2021 |
| Abstract: | Effects of a fixed single meal per day were examined on the circadian pacemaker and sleep-wake cycle in subjects under temporal isolation. When the time of single meal was allowed to take at any time of day (ad-lib meal), the sleep-wake cycle as well as the circadian rhythms in plasma melatonin, cortisol, and core body temperature were significantly phase-delayed in 8 days. On the other hand, when the time of meal was fixed at 1800 h in local time (RF meal), the phase-shift of sleep-wake cycle was not significant while those of the circadian rhythms were significant. The differential effects of a fixed single meal schedule were confirmed in most individual subjects. There was no evidence for the prefeeding increase in plasma cortisol and leptin levels under the fixed single meal schedule. The plasma ghrelin level was apparently high before meal in both ad-lib and RF meal groups, which was, however, likely sculptured by a nonspecific prandial drop and gradual increase after meal intake. Single meal augmented the prandial increase of plasma insulin levels by four to five times. These findings indicate that a single meal at a fixed time of the day during the subjective day failed to prevent the human circadian pacemaker but prevented the sleepwake cycle from free running for at least 8 days under temporal isolation, suggesting that mealtime was a potent nonphotic time cue for the human sleep-wake cycle. |
| Type: | article |
| URI: | http://hdl.handle.net/2115/90116 |
| Appears in Collections: | 教育学院・教育学研究院 (Graduate School of Education / Faculty of Education) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 山仲 勇二郎
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