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Hokkaido University Collection of Scholarly and Academic Papers >
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Necroptosis of neuronal cells is related to the neuropathology of tick-borne encephalitis
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| Title: | Necroptosis of neuronal cells is related to the neuropathology of tick-borne encephalitis |
| Authors: | Tsujino, Dai Browse this author | | Yoshii, Kentaro Browse this author | | Kajiyama, Misa Browse this author | | Takahashi, Yuji Browse this author | | Maekawa, Naoya Browse this author | | Kariwa, Hiroaki Browse this author →KAKEN DB | | Kobayashi, Shintaro Browse this author →KAKEN DB |
| Keywords: | Tick-borne encephalitis virus | | Programmed cell death | | Necroptosis |
| Issue Date: | Nov-2022 |
| Publisher: | Elsevier |
| Journal Title: | Virus Research |
| Volume: | 321 |
| Start Page: | 198914 |
| Publisher DOI: | 10.1016/j.virusres.2022.198914 |
| Abstract: | Tick-borne encephalitis virus (TBEV) is a zoonotic virus that causes tick-borne encephalitis (TBE) in humans. Infections of Sapporo-17-Io1 (Sapporo) and Oshima 5-10 (Oshima) TBEV strains showed different pathogenic effects in mice. However, the differences between the two strains are unknown. In this study, we examined neuronal degeneration and death, and activation of glial cells in mice inoculated with each strain to investigate the pathogenesis of TBE. Viral growth was similar between Sapporo and Oshima, but neuronal degeneration and death, and activation of glial cells, was more prominent with Oshima. In human neuroblastoma cells, apoptosis and pyroptosis were not observed after TBEV infection. However, the expression of the necroptosis marker, mixed lineage kinase domain-like (MLKL) protein, was upregulated by TBEV infection, and this upregulation was more pronounced in Oshima than Sapporo infections. As necroptosis is a pro-inflammatory type of cell death, differences in necroptosis induction might be involved in the differences in neuropathogenicity of TBE. |
| Rights: | © 2022. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/90730 |
| Appears in Collections: | 獣医学院・獣医学研究院 (Graduate School of Veterinary Medicine / Faculty of Veterinary Medicine) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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Submitter: 小林 進太郎
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