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First insight into the genetic population structure of Mycobacterium tuberculosis isolated from pulmonary tuberculosis patients in Egypt

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タイトル: First insight into the genetic population structure of Mycobacterium tuberculosis isolated from pulmonary tuberculosis patients in Egypt
著者: Diab, Hassan Mahmoud 著作を一覧する
Nakajima, Chie 著作を一覧する
Kotb, Saber A. 著作を一覧する
Mokhtar, Alaa 著作を一覧する
Khder, Nagwa F.M. 著作を一覧する
Abdelaal, Ahmed S.A. 著作を一覧する
Hegazy, Azza 著作を一覧する
Poudel, Ajay 著作を一覧する
Shah, Yogendra 著作を一覧する
Suzuki, Yasuhiko 著作を一覧する
キーワード: Genotyping
MTB lineages
Egypt
発行日: 2016年 1月
出版者: Elsevier
誌名: Tuberculosis
巻: 96
開始ページ: 13
終了ページ: 20
出版社 DOI: 10.1016/j.tube.2015.11.002
抄録: The present study aimed to assess the population structure of Mycobacterium tuberculosis (MTB) isolates from Egypt. A total of 230 MTB isolates were analysed using spoligotyping, large sequence polymorphism (LSPs), mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) typing and multi-locus sequence typing (MLST). The majority of isolates (93.0%) belonged to lineage 4, including 44.3, 13.4 and 10.8% of the ill-defined T clade, LAM and Haarlem families, respectively, and lineage 3 was identified in 7.0% of the isolates. MIRU-VNTRs typing allowed efficient discrimination of the spoligotype-defined clusters, including spoligo-international types (SIT) 53, 34, and 4, into 56 patterns, including 13 clusters and 43 unique patterns. A new SNP at position 311614 was identified in all six isolates to form the biggest MIRU-VNTR cluster, which suggested a recent clonal expansion. This SNP could possibly be used as a genetic marker for robust discriminations of Egyptian MTB isolates belonging to SIT53. The combination of spoligotyping, 12 MIRU-VNTRs loci and MLST provided insight into the genetic diversity and transmission dynamics of the Egyptian MTB genotypes and could be a key to implementation of effective control measures by public health authorities.
Rights: ©2015, Elsevier. This manuscript version is made available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/68587
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 鈴木 定彦

 

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