| Title: | Correlation between antibiotic use and resistance of gram-negative bacteria at a university hospital in Japan from 2013 to 2021 : a study using the Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) system |
| Authors: | Kagami, Keisuke Browse this author |
| Ishiguro, Nobuhisa Browse this author →KAKEN DB |
| Iwasaki, Sumio Browse this author |
| Taki, Keisuke Browse this author |
| Fukumoto, Tatsuya Browse this author |
| Hayasaka, Kasumi Browse this author |
| Oyamada, Reiko Browse this author |
| Watanabe, Tsubasa Browse this author |
| Nakakubo, Sho Browse this author |
| Niinuma, Yusuke Browse this author |
| Sugawara, Mitsuru Browse this author |
| Takekuma, Yoh Browse this author →KAKEN DB |
| Keywords: | J-SIPHE |
| surveillance |
| antibiotic use |
| antibiotic resistance |
| carbapenems |
| Issue Date: | 12-Jul-2023 |
| Publisher: | BMJ Publishing Group |
| Journal Title: | European Journal of Hospital Pharmacy |
| Start Page: | ejhpharm-2023-003797 |
| Publisher DOI: | 10.1136/ejhpharm-2023-003797 |
| Abstract: | ObjectivesThe Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) system aggregates information related to antimicrobial resistance (AMR) measures. We aimed to investigate the correlation between antibiotic use and AMR at a university hospital from 2013 to 2021 in a time series analysis using the J-SIPHE system. We also studied this correlation in each ward (inter-ward analysis). MethodsData on antibiotic use and resistance rates were collected from the J-SIPHE system, except for the resistance rate in each ward, which was calculated from the source data prepared for this system. ResultsPiperacillin/tazobactam use was positively correlated with piperacillin/tazobactam resistance in Escherichia coli and Klebsiella pneumoniae in the inter-ward analysis, and in Pseudomonas aeruginosa in both analyses. Carbapenem use was positively correlated with meropenem resistance in Enterobacter cloacae in the time series analysis and in P. aeruginosa in both analyses, and imipenem/cilastatin resistance in P. aeruginosa in inter-ward analysis. Quinolone use was positively correlated with levofloxacin resistance in E. coli in both analyses, and in K. pneumoniae in inter-ward analysis. ConclusionsThis is the first study to investigate the correlation between antibiotic use and AMR at a single hospital in time series and inter-ward analyses using the J-SIPHE system and data prepared for this system, suggesting that this system may be useful for promoting AMR measures. |
| Rights: | This article has been accepted for publication in [European journal of hospital pharmacy, 2023] following peer review, and the Version of Record can be accessed online at http://dx.doi.org/10.1136/ejhpharm-2023-003797. © European Association of Hospital Pharmacists 2023. Reuse of this manuscript version (excluding any databases, tables, diagrams, photographs and other images or illustrative material included where a another copyright owner is identified) is permitted strictly pursuant to the terms of the Creative Commons Attribution-Non Commercial 4.0 International (CC-BY-NC 4.0) http://creativecommons.org |
| Type: | article (author version) |
| URI: | http://hdl.handle.net/2115/92557 |
| Appears in Collections: | 北海道大学病院 (Hokkaido University Hospital) > 雑誌発表論文等 (Peer-reviewed Journal Articles, etc)
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