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Quinolone Resistance Determinants of Clinical Salmonella Enteritidis in Thailand

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この文献へのリンクには次のURLを使用してください:http://hdl.handle.net/2115/71609

タイトル: Quinolone Resistance Determinants of Clinical Salmonella Enteritidis in Thailand
著者: Utrarachkij, Fuangfa 著作を一覧する
Nakajima, Chie 著作を一覧する
Changkwanyeun, Ruchirada 著作を一覧する
Siripanichgon, Kanokrat 著作を一覧する
Kongsoi, Siriporn 著作を一覧する
Pornruangwong, Srirat 著作を一覧する
Changkaew, Kanjana 著作を一覧する
Tsunoda, Risa 著作を一覧する
Tamura, Yutaka 著作を一覧する
Suthienkul, Orasa 著作を一覧する
Suzuki, Yasuhiko 著作を一覧する
キーワード: Salmonella Enteritidis
quinolone resistance
gyrA
qnrS1
MLVA
発行日: 2017年10月 1日
出版者: Mary Ann Liebert
誌名: Microbial drug resistance
巻: 23
号: 7
開始ページ: 885
終了ページ: 894
出版社 DOI: 10.1089/mdr.2015.0234
抄録: Salmonella Enteritidis has emerged as a global concern regarding quinolone resistance and invasive potential. Although quinolone-resistant S. Enteritidis has been observed with high frequency in Thailand, information on the mechanism of resistance acquisition is limited. To elucidate the mechanism, a total of 158 clinical isolates of nalidixic acid (NAL)-resistant S. Enteritidis were collected throughout Thailand, and the quinolone resistance determinants were investigated in the context of resistance levels to NAL, norfloxacin (NOR), and ciprofloxacin (CIP). The analysis of point mutations in type II topoisomerase genes and the detection of plasmid-mediated quinolone resistance genes showed that all but two harbored a gyrA mutation, the qnrS1 gene, or both. The most commonly affected codon in mutant gyrA was 87, followed by 83. Double codon mutation in gyrA was found in an isolate with high-level resistance to NAL, NOR, and CIP. A new mutation causing serine to isoleucine substitution at codon 83 was identified in eight isolates. In addition to eighteen qnrS1-carrying isolates showing nontypical quinolone resistance, one carrying both the qnrS1 gene and a gyrA mutation also showed a high level of resistance. Genotyping by multilocus variable number of tandem repeat analysis suggested a possible clonal expansion of NAL-resistant strains nationwide. Our data suggested that NAL-resistant isolates with single quinolone resistance determinant may potentially become fluoroquinolone resistant by acquiring secondary determinants. Restricted therapeutic and farming usage of quinolones is strongly recommended to prevent the emergence of fluoroquinolone-resistant isolates.
Rights: Final publication is available from Mary Ann Liebert, Inc., publishers https://doi.org/10.1089/mdr.2015.0234
資料タイプ: article (author version)
URI: http://hdl.handle.net/2115/71609
出現コレクション:雑誌発表論文等 (Peer-reviewed Journal Articles, etc)

提供者: 鈴木 定彦

 

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